CSIRO PUBLISHING - Australian Journal of Chemistry

Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Alexander K. L. Yuen ^A , Katrina A. Jolliffe ^A and Craig A. Hutton ^B ^, ^C

^A School of Chemistry, University of Sydney, Sydney NSW 2006, Australia.
^B School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne VIC 3010, Australia.
^C Corresponding author. Email: chutton@unimelb.edu.au

Abstract

The central functionalized tryptophan core of the celogentin/moroidin family of cyclic peptides has been prepared. The strategy incorporates a novel preparation of 4-iodobenzaldehyde and employs a Larock annulation as the key step.

Australian Journal of Chemistry 59(11) 819–826

Submitted: 1 September 2006 Accepted: 2 October 2006 Published: 17 November 2006

Full text DOI: 10.1071/CH06324

© CSIRO 2006