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Article << Previous     |     Next >>   Contents Vol 62(10)

Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

Candy K. Y. Chun A, Richard J. Payne A B

A School of Chemistry, The University of Sydney, NSW 2006, Australia.
B Corresponding author. Email: payne@chem.usyd.edu.au
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Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.

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