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Article << Previous     |     Next >>   Contents Vol 63(10)

Biodegradable PEG Hydrogels Cross-linkedUsing Biotin-Avidin Interactions

Yingkai Liu A, Jingquan Liu B C D, Jiangtao Xu B, Shengyu Feng A D, Thomas P. Davis B D

A Key Laboratory of Special Functional Aggregated Materials, Ministry of Educationand School of Chemistry and Chemical Engineering, Shandong University,Jinan 250100, China.
B Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.
C School of Chemical Engineering, Chemistry and Environment, Qingdao University, Qingdao 266071, China.
D Corresponding authors. Email: fsy@sdu.edu.cn; jingquan.liu@unsw.edu.au; t.davis@unsw.edu.au
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Poly(ethylene glycol) (PEG) hydrogels are water-swellable, non-toxic, non-immunogenic, and biocompatible. In this paper, we describe the generation of biodegradable PEG hydrogels by cross-linking biotinylated PEG oligomers containing intrinsic disulfide bonds via biotin-avidin interactions. The biotinylated PEG oligomers were synthesized by the condensation reaction between PEG and 3,3′-dithiodipropionic acid, followed by the reaction with biotin. This methodology obviates the need for potentially toxic chemical cross-linking agents that are usually used in the common preparation of hydrogels. Therefore it may be particularly useful in biomedical or pharmaceutical applications.

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