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Role of Cation in Enhancing the Conversion of the Alzheimer’s Peptide into Amyloid Fibrils Using Protic Ionic Liquids
Natalie
Debeljuh B,
Swapna
Varghese A,
Colin J.
Barrow B and
Nolene
Byrne A C
A
Institute for Frontier Materials, Deakin University, Geelong, Vic. 3217, Australia.
B
School of Life and Environmental Sciences, Deakin University, Geelong, Vic. 3217, Australia.
C
Corresponding author. Email: nolene.byrne@deakin.edu.au
Australian Journal of Chemistry
65(11)
1502-1506 http://dx.doi.org/10.1071/CH12316
Submitted: 5 July 2012 Accepted: 10 August 2012 Published:
2
October
2012
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Abstract
We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the Aβ 16–22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed. 
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References
[1]
C. M. Dobson, Trends Biochem. Sci. 1999, 24, 329.
| CrossRef | CAS | 
[2]
J. Hardy, D. J. Selkoe, Science 2002, 297, 353.
| CrossRef | CAS |
[3]
C. M. Dobson, Science 2004, 304, 1259.
| CrossRef | CAS |
[4]
C. M. Dobson, Nature 2003, 426, 884.
| CrossRef | CAS |
[5]
M. Fändrich, M. A. Fletcher, C. M. Dobson, Nature 2001, 410, 165.
| CrossRef |
[6]
T. E. Golde, L. S. Schneider, E. H. Koo, Neuron 2011, 69, 203.
| CrossRef | CAS |
[7]
M. T. Pastor, N. Kümmerer, V. Schubert, A. Esteras-Chopo, C. G. Dotti, M. López de la Paz, L. Serrano, J. Mol. Biol. 2008, 375, 695.
| CrossRef | CAS |
[8]
M. P. Mattson, Nature 2004, 430, 631.
| CrossRef | CAS |
[9]
H. A. Lashuel, D. Hartley, B. M. Petre, T. Walz, P. T. Lansbury, Nature 2002, 418, 291.
| CrossRef | CAS |
[10]
D. R. Howlett, K. H. Jennings, D. C. Lee, M. S. G. Clark, F. Brown, R. Wetzel, S. J. Wood, P. Camilleri, G. W. Roberts, Neurodegeneration 1995, 4, 23.
| CrossRef | CAS |
[11]
S. Santini, G. Wei, N. Mousseau, P. Derreumaux, Structure 2004, 12, 1245.
| CrossRef | CAS |
[12]
J. P. Schmittschmitt, J. M. Scholtz, Protein Sci. 2003, 12, 2374.
| CrossRef | CAS |
[13]
C. L. Shen, R. M. Murphy, Biophys. J. 1995, 69, 640.
| CrossRef | CAS |
[14]
H. Weingärtner, C. Cabrele, C. Herrmann, Phys. Chem. Chem. Phys. 2012, 14, 415.
| CrossRef |
[15]
S. N. Baker, T. M. McCleskey, S. Pandey, G. A. Baker, Chem. Commun. 2004, 940.
| CrossRef | CAS |
[16]
K. Fujita, D. R. MacFarlane, M. Forsyth, Chem. Commun. 2005, 4804.
| CrossRef | CAS |
[17]
N. Byrne, L.-M. Wang, J.-P. Belieres, C. A. Angell, Chem. Commun. 2007, 2714.
| CrossRef | CAS |
[18]
H. R. Kalhor, M. Kamizi, J. Akbari, A. Heydari, Biomacromolecules 2009, 10, 2468.
| CrossRef | CAS |
[19]
H. Hwang, H. Choi, H.-k. Kim, D. H. Jo, T. D. Kim, Anal. Biochem. 2009, 386, 293.
| CrossRef | CAS |
[20]
N. Debeljuh, C. J. Barrow, N. Byrne, Phys. Chem. Chem. Phys. 2011, 13, 16534.
| CrossRef | CAS |
[21]
N. Byrne, C. A. Angell, Chem. Commun. 2009, 1046.
| CrossRef | CAS |
[22]
N. Byrne, C. A. Angell, J. Mol. Biol. 2008, 378, 707.
| CrossRef | CAS |
[23]
J. S. Wilkes, P. Wasserscheid, T. Welton, Introduction, in Ionic Liquids in Synthesis 2008, pp. 1–6 (Wiley-VCH: Weinheim).
[24]
J.-P. Belieres, C. A. Angell, J. Phys. Chem. B 2007, 111, 4926.
| CrossRef | CAS |
[25]
J. Stoimenovski, E. I. Izgorodina, D. R. MacFarlane, Phys. Chem. Chem. Phys. 2010, 12, 10341.
| CrossRef | CAS |
[26]
J. P. Mann, A. McCluskey, R. Atkin, Green Chem. 2009, 11, 785.
| CrossRef | CAS |
[27]
N. Byrne, B. Rodoni, F. Constable, S. Varghese, J. H. Davis, Phys. Chem. Chem. Phys. 2012, 14, 10119.
| CrossRef | CAS |
[28]
N. Debeljuh, C. J. Barrow, L. Henderson, N. Byrne, Chem. Commun. 2011, 47, 6371.
| CrossRef | CAS |
[29]
N. Chaudhary, R. Nagaraj, J. Pept. Sci. 2011, 17, 115.
| CrossRef | CAS |
[30]
L. J. Domigan, J. P. Healy, S. J. Meade, R. J. Blaikie, J. A. Gerrard, Biopolymers 2012, 97, 123.
| CrossRef | CAS |
[31]
M. Yoshizawa, W. Xu, C. A. Angell, J. Am. Chem. Soc. 2003, 125, 15411.
| CrossRef | CAS |
|
|
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