References

Barbat, A., Le Mézec, P., Ducrocq, V., Mattalia, S., Fritz, S., Boichard, D., Ponsart, C., and Humblot, P. (2010). Female fertility in French dairy breeds: current situation and strategies for improvement. J. Reprod. Dev. 56, S15–S21.
| CrossRef |

Beam, S. W., and Butler, W. R. (1997). Energy balance and ovarian follicle development prior to first ovulation postpartum in dairy cows receiving three levels of dietary fat. Biol. Reprod. 56, 133–142.
| CrossRef | CAS |

Berry, D. P., Horan, B., O’Donovan, M., Buckley, F., Kennedy, E., McEvoy, M., and Dillon, P. (2007). Genetics of grass dry matter intake, energy balance, and digestibility in grazing Irish dairy cows. J. Dairy Sci. 90, 4835–4845.
| CrossRef | CAS |

Britt, J. H. (1994). Follicular development and fertility: Potential impacts of negative energy balance. In ‘Proceedings of the National Reproduction Symposium, Pittsburgh’. (Ed. Ellen Rae Jordan.) pp. 103–112.

Cassell, B. G., Adamec, V., and Pearson, R. E. (2003). Maternal and fetal inbreeding depression for 70-day nonreturn and calving rate in Holsteins and Jerseys. J. Dairy Sci. 86, 2977–2983.
| CrossRef | CAS |

Cerri, R. L. A., Rutigliano, H. M., Chebel, R. C., and Santos, J. E. P. (2009a). Period of dominance of the ovulatory follicle influences embryo quality in lactating dairy cows. Reproduction 137, 813–823.
| CrossRef | CAS |

Cerri, R. L. A., Juchem, S. O., Chebel, R. C., Rutigliano, H. M., Bruno, R. G. S., Galvao, K. N., Thatcher, W. W., and Santos, J. E. P. (2009b). Effect of fat source differing in fatty acid profile on metabolic parameters, fertilization, and embryo quality in high-producing dairy cows. J. Dairy Sci. 92, 1520–1531.
| CrossRef | CAS |

Diskin, M. G. (2008). Reproductive management of dairy cows: A Review (Part 1). Ir. Vet. J. 61, 233–239.

Diskin, M. G., Stronge, A. J. H., Morris, D. G., Kenny, D. A., and Sreenan, J. M. (2004). The association between early luteal phase concentrations of progesterone and embryo survival in heifers and dairy cows. J. Anim. Sci. 82, 101..

Diskin, M. G., Murphy, J. J., and Sreenan, J. M. (2006). Embryo survival in dairy cows managed under pastoral conditions. Anim. Reprod. Sci. 96, 297–311.
| CrossRef | CAS |

Dunne, L. D., Diskin, M. G., Boland, M. P., O’Farrell, K. J., and Sreenan, J. M. (1999). The effects of pre-and post-insemination plane of nutrition on embryo survival in beef heifers. Anim. Sci. 69, 411–417.

Forde, N., Beltman, M. E., Duffy, G. B., Duffy, P., Mehta, J. P., O’Gaora, P., Roche, J. F., Lonergan, P., and Crowe, M. A. (2011). Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation. Biol. Reprod. 84, 266–278.
| CrossRef | CAS |

Fouladi-Nashta, A. A., Gutierrex, C. G., Garnsworthy, P. C., and Webb, R. (2005). Effects of dietary carbohydrate source on oocyte/embryo quality and development in high-yielding, lactating dairy cattle. In ‘Program for the 38th Annual Meeting, Society for the Study of Reproduction, Quebec City’. pp. 135–136. (Society for the Study of Reproduction: Madison, WI.). [Abstract]

Freret, S., Grimard, B., Ponter, A. A., Joly, C., Ponsart, C., and Humblot, P. (2006). Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers. Reproduction 131, 783–794.
| CrossRef | CAS |

Friggens, N. C., Disenhaus, C., and Petit, H. V. (2010). Nutritional sub-fertility in the dairy cow: towards improved reproductive management through a better biological understanding. Animal 4, 1197–1213.
| CrossRef |

Garnsworthy, P. G., Lock, A., Mann, G. E., Sinclair, K. D., and Webb, R. (2008a). Nutrition, metabolism, and fertility in dairy cows: 1. dietary energy source and ovarian function. J. Dairy Sci. 91, 3814–3823.
| CrossRef | CAS |

Garnsworthy, P. G., Sinclair, K. D., and Webb, R. (2008b). Integration of physiological mechanisms that influence fertility in dairy cows. Animal 2, 1144–1152.
| CrossRef |

Garnsworthy, P. C., Fouladi-Nashta, A. A., Mann, G. E., Sinclair, K. D., and Webb, R. (2009). Effect of diet induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows. Reproduction 137, 759–768.
| CrossRef | CAS |

Garrett, J. E., Geisert, R. D., Zavy, M. T., and Morgan, G. L. (1988). Evidence for maternal regulation of early conceptus growth and development in beef cattle. J. Reprod. Fertil. 84, 437–446.
| CrossRef | CAS |

Georges, M., and Massey, J. M. (1991). Velogenetics, or the synergistic use of marker assisted selection and germ-line manipulation. Theriogenology 35, 151–159.
| CrossRef |

Gong, J. G., Lee, W. J., Garnsworthy, P. C., and Webb, R. (2002). Effect of dietary-induced increases in circulating insulin concentrations during the early postpartum period on reproductive function in dairy cows. Reproduction 123, 419–427.
| CrossRef | CAS |

Grimard, B., Freret, S., Chevallier, A., Pinto, A., Ponsart, C., and Humblot, P. (2006). Genetic and environmental factors influencing first service conception rate and late embryonic/foetal mortality in low fertility dairy herds. Anim. Reprod. Sci. 91, 31–44.
| CrossRef | CAS |

Gustavsson, I. (1979). Distribution and effects of the 1.29 Robertsonian translocation in cattle. J. Dairy Sci. 62, 825–835.
| CrossRef | CAS |

Harris, B. L., and Kolver, E. S. (2001). Review of Holsteinization on intensive pastoral dairy farming in New Zealand. J. Dairy Sci. 84, E56–E61.
| CrossRef | CAS |

Horan, B., Mee, J. F., Rath, M., O’Connor, P., and Dillon, P. (2004). The effect of strain of Holstein-Friesian cow and feeding system on reproductive performance in seasonal-calving milk production systems. Anim. Sci. 79, 453–467.

Humblot, P. (2001). Use of pregnancy specific proteins and progesterone assays to monitor pregnancy and determine the timing, frequencies and sources of embryonic mortality. Theriogenology 56, 1417–1433.
| CrossRef | CAS |

Humblot, P., Le Bourhis, D., Fritz, S., Colleau, J. J., Gonzalez, C., Guyader Joly, C., Malafosse, A., Heyman, Y., Amigues, Y., Tissier, M., and Ponsart, C. (2010). Reproductive technologies and genomic selection in cattle. Vet. Med. Int. 24, Article ID 192787..

Kennedy, J., Dillon, P., O’Sullivan, K., Buckley, F., and Rath, M. (2003). The effect of genetic merit for milk production and concentrate feeding level on reproductive performance of Holstein-Friesian cows in a grass-based system. Anim. Sci. 76, 297–308.

Kerbler, T. L., Buhr, M. M., Jordan, L. T., Leslie, K. E., and Walton, J. S. (1997). Relationship between maternal plasma progesterone concentration and interferon-tau synthesis by the conceptus in cattle. Theriogenology 47, 703–714.
| CrossRef | CAS |

Kuhn, M. T., Hutchison, J. L., and Wiggans, G. R. (2006). Characterization of Holstein heifer fertility in the United States. J. Dairy Sci. 89, 4907–4920.
| CrossRef | CAS |

Leroy, J. L. M. R., Van Soom, A., Opsomer, G., and Bols, R. E. J. (2008). The consequences of metabolic changes in high-yielding diary cows on oocyte and embryo quality. Animal 2, 1120–1127.
| CrossRef |

McNeill, R. E., Sreenan, J. M., Diskin, M. G., Cairns, M. T., Fitzpatrick, R., Smith, T. J., and Morris, D. M. (2006). Effect of progesterone concentration on the expression of progesterone-responsive genes in the bovine endometrium during the early luteal phase. Reprod. Fertil. Dev. 18, 573–583.
| CrossRef | CAS |

Morris, D. G., Waters, S., McCarthy, S., Patton, J., Earley, B., Fitzpatrick, R., Murphy, J. J., Diskin, M. G., Kenny, D., Brass, A., and Wathes, D. A. (2009). Pleiotropic effects of negative energy balance in the post partum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity. Physiol. Genomics 39, 28–37.
| CrossRef | CAS |

Nebel, R., and McGilliard, M. (1993). Interactions of high milk yield and reproductive performance in dairy cows. J. Dairy Sci. 76, 3257–3268.
| CrossRef | CAS |

Patton, J., Kenny, D. A., McNamara, S., Mee, J. F., O’Mara, F. P., Diskin, M. G., and Murphy, J. J. (2007). Relationships between milk production, energy balance, plasma analytes and reproduction in Holstein-Friesian cows. J. Dairy Sci. 90, 649–658.
| CrossRef | CAS |

Persson, A. (2003). Effect of the genetic defect Complex Vertebral Malformation on fertility in Swedish Holstein cattle. Undergraduate Thesis. Swedish Agricultural University, Uppsala.

Robinson, J. L., Dombrowski, D. B., Harpestad, G. W., and Shanks, R. D. (1984). Detection and prevalence of UMP synthase deficiency among dairy cattle. J. Hered. 75, 277–280.
| CAS |

Rohrer, G. A. (2004). An overview of genomics research and its impact on livestock reproduction. Reprod. Fertil. Dev. 16, 47–54.
| CrossRef | CAS |

Ryan, D. P., Prichard, J. F., Kopel, E., and Godke, R. A. (1993). Comparing early embryo mortality in dairy cows during hot and cool seasons of the year. Theriogenology 39, 719–737.
| CrossRef | CAS |

Sangsritavong, S., Combs, D. K., Sartori, R. F., Armentano, L. E., and Wiltbank, M. C. (2002). High Feed intake increases liver blood flow and metabolism of progesterone and estradiol 17β in dairy cattle. J. Dairy Sci. 85, 2831–2842.
| CrossRef | CAS |

Santos, J. E., Thatcher, W. W., Chebel, R. C., Cerri, R. L., and Galvão, K. N. (2004). The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs. Anim. Reprod. Sci. 82–83, 513–535.
| CrossRef |

Sartori, R., Sartori-Bergfelt, R., Mertens, S. A., Guenther, J. N., Parish, J. J., and Wiltbank, M. C. (2002). Fertilization and early embryonic development in heifers and lactating cows in summer and lactating and dry cows in winter. J. Dairy Sci. 85, 2803–2812.
| CrossRef | CAS |

Shanks, R. D., and Robinson, J. L. (1989). Embryonic mortality attributed to inherited deficiency of uridine monophosphate synthase. J. Dairy Sci. 72, 3035–3039.
| CrossRef | CAS |

Silke, V., Diskin, M. G., Kenny, D. A., Boland, M. P., Dillon, P., Mee, J. F., and Sreenan, J. M. (2001). Extent, pattern and factors associated with late embryonic loss in dairy cows. Anim. Reprod. Sci. 15, 1–12.

Sreenan, J. M., and Diskin, M. G. (1986). The extent and timing of embryonic mortality in cattle. In ‘Embryonic Mortality in Farm Animals’. (Eds J. M. Sreenan and M. G. Diskin.) pp. 142–158. (Martinus Nijhoff, CEC: The Hague.)

Starbuck, G. R., Darwash, A. O., Mann, G. E., and Lamming, G. E. (2001). The detection and treatment of post-insemination progesterone insufficiency in dairy cows. BSAS Occas. Pub. 26, 447–450.

Stronge, A. J. H., Sreenan, J. M., Diskin, M. G., Mee, J. F., Kenny, D. A., and Morris, D. G. (2005). Post-insemination milk progesterone concentration and embryo survival in dairy cows. Theriogenology 64, 1212–1224.
| CrossRef | CAS |

van Knegsel, A. T. M., van den Brand, H., Dijkstra, J., Tamminga, S., and Kemp, B. (2005). Effect of dietary energy source on energy balance, production, metabolic disorders and reproduction in lactating dairy cattle. Reprod. Nutr. Dev. 45, 665–688.
| CrossRef | CAS |

VanRaden, P. M., and Miller, R. H. (2006). Effects of nonadditive genetic interactions, inbreeding and recessive defects on embryo and fetal loss by seventy days. J. Dairy Sci. 89, 2716–2721.
| CrossRef | CAS |

Wall, E., Brotherstone, S., Kearney, J. F., Wolliams, J. A., and Coffey, M. P. (2003). Effect of including inbreeding, heterosis and recombination loss in prediction of breeding values for fertility traits. Interbull. Bull. 31, 117–121.

Wathes, D. C., Cheng, Z., Chowdhury, W., Fenwick, M. A., Fitzpatrick, R., Morris, D. G., Patton, J., and Murphy, J. J. (2009). Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows. Physiol. Genomics 39, 1–13.
| CrossRef | CAS |

Wiebold, J. L. (1988). Embryonic mortality and the uterine environment in first service lactating dairy cows. J. Reprod. Fertil. 84, 393–399.
| CrossRef | CAS |