The sustainable livelihoods approach is widely used in rural development internationally but has been little applied in Australia. It is a framework for thinking and communicating about factors that impact on the livelihoods of individuals and families including their health, well being and income and the maintenance of natural resource condition. The approach aims to promote a systemic understanding of how multiple variables impact on local people’s livelihoods. Three case studies are outlined, that highlight its potential as a tool for collaborative engagement of researchers, local people and other stakeholders, to promote sustainability of Aboriginal livelihood systems in remote desert Australia and to contribute to improved understanding of the dynamics of regional socio-ecological systems.