Animal Production Science Animal Production Science Society
Food, fibre and pharmaceuticals from animals
RESEARCH ARTICLE

Detection of candidate genes for growth and carcass traits using genome-wide association strategy in Chinese Simmental beef cattle

Wengang Zhang A , Lingyang Xu A , Huijiang Gao A , Yang Wu A B , Xue Gao A , Lupei Zhang A , Bo Zhu A , Yuxin Song A , Jinshan Bao C , Junya Li A D and Yan Chen A D
+ Author Affiliations
- Author Affiliations

A Institute of Animal Science, Chinese Academy of Agricultural Science, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China.

B Queensland Brain Institute, The University of Queensland, Brisbane, Qld 4072, Australia.

C Veterinary Bureau of Wulagai Precinct in Xilin Gol League, Wulagai 026321, China.

D Corresponding author. Email: JL1@iascaas.net.cn; chenyan0204@163.com

Animal Production Science - https://doi.org/10.1071/AN16165
Submitted: 17 March 2016  Accepted: 17 August 2016   Published online: 9 November 2016

Abstract

In Chinese beef cattle industry, there are more than 60 million livestock, nearly half of which are Chinese Simmental beef cattle or Simmental crossbreds. Over the past decades, numerous quantitative trait loci for economic traits in cattle have been identified, while few studies for growth and carcass traits have been reported in Simmental beef cattle. In the present study, we conducted genome-wide association study based on BovineHD BeadChip and identified 41, 15, 3, 22 and 16 single-nucleotide polymorphisms significantly associated with average daily gain, liveweight before slaughter, carcass weight, dressing percentage and pure meat percentage respectively. In total, 18 candidate genes were found for growth and carcass traits, and four haplotype blocks for growth and carcass traits were discovered. These findings will facilitate detection of major genes and genetic variants involved in growth and carcass traits of beef cattle in further studies.

Additional keywords: Average Daily Gain, Dressing Percentage, Genome-wide Association Study, Quantitative Trait Loci.


References

Al-Mamun HA, Kwan P, Clark SA, Ferdosi MH, Tellam R, Gondro C (2015) Genome-wide association study of body weight in Australian Merino sheep reveals an orthologous region on OAR6 to human and bovine genomic regions affecting height and weight. Genetics, Selection, Evolution 47,
Genome-wide association study of body weight in Australian Merino sheep reveals an orthologous region on OAR6 to human and bovine genomic regions affecting height and weight.CrossRef |

Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR,, et al (2012) FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Developmental Biology 369, 340–348.

Ball AR Ball AR (2002) Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. Molecular and Cellular Biology 22, 5769–5781.

Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschke P, Salomon R, Antignac C (2012) FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental Cell 22, 1191–1207.

Boyko AR, Brooks SA, Behan-Braman A, Castelhano M, Corey E, Oliveira KC, Swinburne JE, Todhunter RJ, Zhang Z, Ainsworth DM, Robinson NE (2014) Genomic analysis establishes correlation between growth and laryngeal neuropathy in thoroughbreds. BMC Genomics 15, 259
Genomic analysis establishes correlation between growth and laryngeal neuropathy in thoroughbreds.CrossRef |

Browning BL, Browning SR (2009) A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. American Journal of Human Genetics 84, 210–223.
A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals.CrossRef | 1:CAS:528:DC%2BD1MXisFCrtL8%3D&md5=7cfc4497695ca3585d1da74117f4526dCAS |

Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (2002) Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway. The Journal of Bological Chemistry 277, 29503–29509.

Chang CB, Hemmati-Brivanlou A (1999) Xenopus GDF6, a new antagonist of noggin and a partner of BMPs. Development 126, 3347–3357.

Costa RB, Camargo GMF, Diaz IDPS, Irano N, Dias MM, Carvalheiro R, Boligon AA, Baldi F, Oliveira HN, Tonhati H, Albuquerque LG (2015) Genome-wide association study of reproductive traits in Nellore heifers using Bayesian inference. Genetics, Selection, Evolution. 47, 67
Genome-wide association study of reproductive traits in Nellore heifers using Bayesian inference.CrossRef |

de Pontual L, Mathieu Y, Golzio C, Rio M, Malan V, Boddaert N, Soufflet C, Picard C, Durandy A, Dobbie A,, et al (2009) Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome. Human Mutation 30, 669–676.

Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, Diaz-Arrastia R, Brunskill EW, Potter SS, McKnight SL (2004) Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proceedings of the National Academy of Sciences of the United States of America 101, 13648–13653.

Evangelista M, Zigmond S, Boone C (2003) Formins: signaling effectors for assembly and polarization of actin filaments. Journal of Cell Science 116, 2603–2611.
Formins: signaling effectors for assembly and polarization of actin filaments.CrossRef | 1:CAS:528:DC%2BD3sXlsFamtL0%3D&md5=61fa02fd03f3d18c1aff50d5f632db5dCAS |

Fan H, Wu Y, Zhou X, Xia J, Zhang W, Song Y, Liu F, Chen Y, Zhang L, Gao X, Gao H, Li J (2015) Pathway-based genome-wide association studies for two meat production traits in Simmental cattle. Scientific Reports 5, 18389
Pathway-based genome-wide association studies for two meat production traits in Simmental cattle.CrossRef | 1:CAS:528:DC%2BC2MXitVCltLnL&md5=cb287ef844ac7b6d12fabc5764869a35CAS |

Faix J, Grosse R (2006) Staying in shape with formins. Developmental Cell 10, 693–706.

Fritz TA, Raman J, Tabak LA (2006) Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2. The Journal of Biological Chemistry 281, 8613–8619.

Garcia MD, Matukumalli L, Wheeler TL, Shackelford SD, Smith TP, Casas E (2010) Markers on bovine chromosome 20 associated with carcass quality and composition traits and incidence of contracting infectious bovine keratoconjunctivitis. Animal Biotechnology 21, 188–202.
Markers on bovine chromosome 20 associated with carcass quality and composition traits and incidence of contracting infectious bovine keratoconjunctivitis.CrossRef | 1:CAS:528:DC%2BC3cXpsVCgt7c%3D&md5=61574fefa4dc574750d83387d8d93a99CAS |

Han B, Kang HM, Eskin E (2009) Rapid and accurate multiple testing correction and power estimation for millions of correlated markers. PLOS Genetics 5, e1000456
Rapid and accurate multiple testing correction and power estimation for millions of correlated markers.CrossRef |

Hu J, Lu J, Lian G, Ferland RJ, Dettenhofer M, Sheen VL (2014) Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Human Molecular Genetics 23, 4663–4673.
Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate.CrossRef | 1:CAS:528:DC%2BC2cXht1OrsbrO&md5=b7f5a8adc5d9aa2965e005c978d32d8aCAS |

Iwasaki H, Zhang Y, Tachibana K, Gotoh M, Kikuchi N, Kwon YD, Togayachi A, Kudo T, Kubota T, Narimatsu H (2003) Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. The Journal of biological chemistry 278, 5613–5621.

Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, et al (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor beta (TGFbeta) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. The Journal of biological chemistry 287, 2353–2363.

Jiang L, Liu JF, Sun DX, Ma PP, Ding XD, Yu Y, Zhang Q (2010) Genome wide association studies for milk production traits in Chinese Holstein population. PLoS One 5,
Genome wide association studies for milk production traits in Chinese Holstein population.CrossRef |

Kemper KE, Daetwyler HD, Visscher PM, Goddard ME (2012) Comparing linkage and association analyses in sheep points to a better way of doing GWAS. Genetical Research 94, 191–203.
Comparing linkage and association analyses in sheep points to a better way of doing GWAS.CrossRef | 1:CAS:528:DC%2BC38XhtlWhsr%2FL&md5=3e1ad5753eeafcd33030f788171c4e8bCAS |

Lee SH, DeCandia TR, Ripke S, Yang J, Sullivan PF, Goddard ME, Keller MC, Visscher PM, Wray NR, Schizophrenia Psychiatric Genome-wide Association Study Consortium (PGC–SCZ) International Schizophrenia Consortium (ISC) Molecular Genetics of Schizophrenia Collaboration (MGS) (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nature Genetics 44, 247–250.
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.CrossRef | 1:CAS:528:DC%2BC38XisVKrsr8%3D&md5=e449d8c860d861daa73f84e8fb7cfd94CAS |

Li C, Basarab J, Snelling WM, Benkel B, Murdoch B, Moore SS (2002) The identification of common haplotypes on bovine chromosome 5 within commercial lines of Bos taurus and their associations with growth traits. Journal of Animal Science 80, 1187–1194.
The identification of common haplotypes on bovine chromosome 5 within commercial lines of Bos taurus and their associations with growth traits.CrossRef | 1:CAS:528:DC%2BD38XmvVeksb4%3D&md5=28eba1cd7358bc2007c8f91ff2ae3487CAS |

Lindholm-Perry AK, Sexten AK, Kuehn LA, Smith TP, King DA, Shackelford SD, Wheeler TL, Ferrell CL, Jenkins TG, Snelling WM, Freetly HC (2011) Association, effects and validation of polymorphisms within the NCAPGLCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. BMC Genetics 12, 103
Association, effects and validation of polymorphisms within the NCAPGLCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle.CrossRef | 1:CAS:528:DC%2BC38Xkslagt7s%3D&md5=ba02afe465e7b798c2fcf2247dee9c2fCAS |

Lindholm-Perry AK, Kuehn LA, Oliver WT, Sexten AK, Miles JR, Rempel LA, Cushman RA, Freetly HC (2013) Adipose and muscle tissue gene expression of two genes (NCAPG and LCORL) located in a chromosomal region associated with cattle feed intake and gain. PLoS One 8, e80882
Adipose and muscle tissue gene expression of two genes (NCAPG and LCORL) located in a chromosomal region associated with cattle feed intake and gain.CrossRef |

MacNeil MD, Grosz MD (2002) Genome-wide scans for QTL affecting carcass traits in Hereford × composite double backcross populations. Journal of Animal Science 80, 2316–2324.
Genome-wide scans for QTL affecting carcass traits in Hereford × composite double backcross populations.CrossRef | 1:CAS:528:DC%2BD38XntVygsLc%3D&md5=2f14537cf8b1a3cf5d2f96e414bea196CAS |

Makvandi-Nejad S, Hoffman GE, Allen JJ, Chu E, Gu E, Chandler AM, Loredo AI, Bellone RR, Mezey JG, Brooks SA, Sutter NB (2012) Four loci explain 83% of size variation in the horse. PLoS One 7, e39929
Four loci explain 83% of size variation in the horse.CrossRef | 1:CAS:528:DC%2BC38XhtVKrsrrE&md5=89d1342b7d7d0a52dd6ba566d68148b3CAS |

Matsushima M, Takahashi T, Ichinose M, Miki K, Kurokawa K, Takahashi K (1991) Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. Biochemical and Biophysical Research Communications 178, 1459–1464.

Martinez A, Aldai N, Celaya R, Osoro K (2010) Effect of breed body size and the muscular hypertrophy gene in the production and carcass traits of concentrate-finished yearling bulls. Journal of Animal Science 88, 1229–1239.
Effect of breed body size and the muscular hypertrophy gene in the production and carcass traits of concentrate-finished yearling bulls.CrossRef | 1:CAS:528:DC%2BC3cXksVCgurs%3D&md5=14baed4ebeb0abdaceeaaefc9eca5183CAS |

Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T, Kurokawa T (1993) Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Molecular and Cellular Biology 13, 4251–4259.
Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.CrossRef | 1:CAS:528:DyaK3sXmsVWmu7k%3D&md5=03aa74ecb26cf2fb7fdbc0ea3f13e0a1CAS |

Mizoshita K, Watanabe T, Hayashi H, Kubota C, Yamakuchi H, Todoroki J, Sugimoto Y (2004) Quantitative trait loci analysis for growth and carcass traits in a half-sib family of purebred Japanese black (Wagyu) cattle. Journal of Animal Science 82, 3415–3420.
Quantitative trait loci analysis for growth and carcass traits in a half-sib family of purebred Japanese black (Wagyu) cattle.CrossRef | 1:CAS:528:DC%2BD2cXhtVGjtbnP&md5=a8cced9318b78b29960558904a05b512CAS |

Morris CA, Bottema CD, Cullen NG, Hickey SM, Esmailizadeh AK, Siebert BD, Pitchford WS (2010) Quantitative trait loci for organ weights and adipose fat composition in Jersey and Limousin back-cross cattle finished on pasture or feedlot. Animal Genetics 41, 589–596.
Quantitative trait loci for organ weights and adipose fat composition in Jersey and Limousin back-cross cattle finished on pasture or feedlot.CrossRef | 1:STN:280:DC%2BC3cblvVGjtg%3D%3D&md5=4ce6b3833fedb82d158e2e46ac2be26cCAS |

Nishimura S, Watanabe T, Mizoshita K, Tatsuda K, Fujita T, Watanabe N, Sugimoto Y, Takasuga A (2012) Genome-wide association study identified three major QTL for carcass weight including the PLAG1CHCHD7 QTN for stature in Japanese black cattle. BMC Genetics 13, 40
Genome-wide association study identified three major QTL for carcass weight including the PLAG1CHCHD7 QTN for stature in Japanese black cattle.CrossRef | 1:CAS:528:DC%2BC38XhtFeis77P&md5=5451821f1aeff13355597a31febb94bdCAS |

Nkrumah JD, Sherman EL, Li C, Marques E, Crews DH, Bartusiak R, Murdoch B, Wang Z, Basarab JA, Moore SS (2007) Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle. Journal of Animal Science 85, 3170–3181.
Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle.CrossRef | 1:CAS:528:DC%2BD2sXhtl2ru7nM&md5=5ed2f8f610d71f5044985e6ca000e0c4CAS |

Ohta Y, Hartwig JH, Stossel TP (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nature Cell Biology 8, 803–814.

Owens FN, Gill DR, Secrist DS, Coleman SW (1995) Review of some aspects of growth and development of feedlot cattle. Journal of Animal Science 73, 3152–3172.
Review of some aspects of growth and development of feedlot cattle.CrossRef | 1:CAS:528:DyaK2MXovVGqsLg%3D&md5=9ef24289e57f97bcd72f7cc6f0c9a614CAS |

Patterson N, Price AL, Reich D (2006) Population structure and eigenanalysis. PLOS Genetics 2, e190
Population structure and eigenanalysis.CrossRef |

Pritchard JK, Stephens M, Rosenberg NA, Donnelly P (2000) Association mapping in structured populations. American Journal of Human Genetics 67, 170–181.
Association mapping in structured populations.CrossRef | 1:STN:280:DC%2BD3czptVWnuw%3D%3D&md5=1aab63e9b9cc122734d6f62a7ef8fc84CAS |

Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics 81, 559–575.
PLINK: a tool set for whole-genome association and population-based linkage analyses.CrossRef | 1:CAS:528:DC%2BD2sXhtVSqurrL&md5=f0d0facf8f1583321fc8113ed752b5d2CAS |

Reber I, Keller I, Becker D, Flury C, Welle M, Drogemuller C (2015) Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10. Animal Genetics 46, 316–320.
Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10.CrossRef | 1:CAS:528:DC%2BC2MXntFGhtrk%3D&md5=c2a3b173b6f6806cd78dedbf67257e65CAS |

Rolf M, Taylor J, Schnabel R, McKay S, McClure M, Northcutt S, Kerley M, Weaber R (2012) Genome-wide association analysis for feed efficiency in Angus cattle. Animal Genetics 43, 367–374.
Genome-wide association analysis for feed efficiency in Angus cattle.CrossRef | 1:CAS:528:DC%2BC38XhtlCqtrvF&md5=5c9c35e514b14108cfccb3e7fdcbf2a4CAS |

Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, et al (2014) A proteome-scale map of the human interactome network. Cell 159, 1212–1226.

Saatchi M, Schnabel RD, Taylor JF, Garrick DJ (2014) Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds. BMC Genomics 15, 442
Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds.CrossRef |

Sahana G, Hoglund JK, Guldbrandtsen B, Lund MS (2015) Loci associated with adult stature also affect calf birth survival in cattle. BMC Genetics 16, 47
Loci associated with adult stature also affect calf birth survival in cattle.CrossRef |

Santana MHA, Utsunomiya YT, Neves HHR, Gomes RC, Garcia JF, Fukumasu H, Silva SL, Leme PR, Coutinho LL, Eler JP, Ferraz JBS (2014) Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus). Journal of Animal Breeding and Genetics 131, 210–216.
Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus).CrossRef | 1:CAS:528:DC%2BC2cXot1yhsbw%3D&md5=0279bed3444dcc8cc02edd1b4d45a994CAS |

Sbarra F, Mantovani R, Bittante G (2010) Heritability of performance test traits in Chianina, Marchigiana and Romagnola breeds. Italian Journal of Animal Science 8, 107–109.
Heritability of performance test traits in Chianina, Marchigiana and Romagnola breeds.CrossRef |

Settle SH Settle SH (2003) Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Developmental biology 254, 116–130.

Shan N, Zhang X, Xiao X, Zhang H, Tong C, Luo X, Chen Y, Liu X, Yin N, Deng Q (2015a) Laminin alpha4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas. Placenta 36, 809–820.

Shan N, Zhang X, Xiao X, Zhang H, Chen Y, Luo X, Liu X, Zhuang B, Peng W, Qi H (2015b) The Role of Laminin alpha4 in Human Umbilical Vein Endothelial Cells and Pathological Mechanism of Preeclampsia. Reproductive sciences 22, 969–979.

Sorbolini S, Marras G, Gaspa G, Dimauro C, Cellesi M, Valentini A, Macciotta NPP (2015) Detection of selection signatures in Piemontese and Marchigiana cattle, two breeds with similar production aptitudes but different selection histories. Genetics, Selection, Evolution 47, 52
Detection of selection signatures in Piemontese and Marchigiana cattle, two breeds with similar production aptitudes but different selection histories.CrossRef |

Stone RT, Keele JW, Shackelford SD, Kappes SM, Koohmaraie M (1999) A primary screen of the bovine genome for quantitative trait loci affecting carcass and growth traits. Journal of Animal Science 77, 1379–1384.
A primary screen of the bovine genome for quantitative trait loci affecting carcass and growth traits.CrossRef | 1:CAS:528:DyaK1MXjs1eqtrY%3D&md5=853818161404b51586aa40cf6a0b3509CAS |

Sun YF, Liu RR, Zhao GP, Zheng MQ, Sun Y, Yu XQ, Li P, Wen J (2014) Genome-wide linkage analysis and association study identifies loci for polydactyly in chickens. G3-Genes Genomes Genetics 4, 1167–1172.

Sztal TE, Sonntag C, Hall TE, Currie PD (2012) Epistatic dissection of laminin-receptor interactions in dystrophic zebrafish muscle. Human Molecular Genetics 21, 4718–4731.
Epistatic dissection of laminin-receptor interactions in dystrophic zebrafish muscle.CrossRef | 1:CAS:528:DC%2BC38XhsFCgsLjL&md5=01e1278c717ca090c29427c229cb9641CAS |

Tabor HK, Risch NJ, Myers RM (2002) Candidate-gene approaches for studying complex genetic traits: practical considerations. Nature Reviews. Genetics 3, 391–397.
Candidate-gene approaches for studying complex genetic traits: practical considerations.CrossRef | 1:CAS:528:DC%2BD38Xjs1yhtb4%3D&md5=e4d4c53f7d8a27850d0faf412573fdf8CAS |

Takasuga A, Watanabe T, Mizoguchi Y, Hirano T, Ihara N, Takano A, Yokouchi K, Fujikawa A, Chiba K, Kobayashi N, Tatsuda K, Oe T, Furukawa-Kuroiwa M, Nishimura-Abe A, Fujita T, Inoue K, Mizoshita K, Ogino A, Sugimoto Y (2007) Identification of bovine QTL for growth and carcass traits in Japanese black cattle by replication and identical-by-descent mapping. Mammalian Genome 18, 125–136.
Identification of bovine QTL for growth and carcass traits in Japanese black cattle by replication and identical-by-descent mapping.CrossRef |

Vaicik MK, Thyboll Kortesmaa J, Moverare-Skrtic S, Kortesmaa J, Soininen R, Bergstrom G, Ohlsson C, Chong LY, Rozell B, Emont M, Cohen RN, Brey EM, Tryggvason K (2014) Laminin alpha4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS One 9, e109854
Laminin alpha4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain.CrossRef |

Vlaming ML, Lagas JS, Schinkel AH (2009) Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice. Advanced Drug Delivery Reviews 61, 14–25.
Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice.CrossRef | 1:CAS:528:DC%2BD1MXhs1alu78%3D&md5=a027cb8bfdeac4029ff8d7c333c0fa8bCAS |

Wu Y, Fan H, Wang Y, Zhang L, Gao X, Chen Y, Li J, Ren H, Gao H (2014) Genome-wide association studies using haplotypes and individual SNPs in Simmental cattle. PLoS One 9, e109330
Genome-wide association studies using haplotypes and individual SNPs in Simmental cattle.CrossRef |

Wu XP, Lund MS, Sahana G, Guldbrandtsen B, Sun DX, Zhang Q, Su GS (2015) Association analysis for udder health based on SNP-panel and sequence data in Danish Holsteins. Genetics, Selection, Evolution 47,
Association analysis for udder health based on SNP-panel and sequence data in Danish Holsteins.CrossRef |

Xiong X, Liu X, Zhou L, Yang J, Yang B, Ma H, Xie X, Huang Y, Fang S, Xiao S, Ren J, Chen C, Ma J, Huang L (2015) Genome-wide association analysis reveals genetic loci and candidate genes for meat quality traits in Chinese Laiwu pigs. Mammalian Genome 26, 181–190.
Genome-wide association analysis reveals genetic loci and candidate genes for meat quality traits in Chinese Laiwu pigs.CrossRef |

Yang JA, Lee SH, Goddard ME, Visscher PM (2011) GCTA: a tool for genome-wide complex trait analysis. American Journal of Human Genetics 88, 76–82.
GCTA: a tool for genome-wide complex trait analysis.CrossRef | 1:CAS:528:DC%2BC3MXktVejtg%3D%3D&md5=50d56acee53be63b3a3e27a6b9155bc0CAS |

Yang Y, Hwang CK, D’Souza UM, Lee SH, Junn E, Mouradian MM (2000) Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. The Journal of Biological Chemistry 275, 20734–20741.

Yu J, Pressoir G, Briggs WH, Vroh Bi I, Yamasaki M, Doebley JF, McMullen MD, Gaut BS, Nielsen DM, Holland JB, Kresovich S, Buckler ES (2006) A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. Nature Genetics 38, 203–208.
A unified mixed-model method for association mapping that accounts for multiple levels of relatedness.CrossRef | 1:CAS:528:DC%2BD28XotlGmuw%3D%3D&md5=e62b39b9602016fc49df3a40b1f7f9b9CAS |

Zhang Z, Buckler ES, Casstevens TM, Bradbury PJ (2009) Software engineering the mixed model for genome-wide association studies on large samples. Briefings in Bioinformatics 10, 664–675.
Software engineering the mixed model for genome-wide association studies on large samples.CrossRef |

Zhao K, Aranzana MJ, Kim S, Lister C, Shindo C, Tang C, Toomajian C, Zheng H, Dean C, Marjoram P, Nordborg M (2007) An Arabidopsis example of association mapping in structured samples. PLOS Genetics 3, e4
An Arabidopsis example of association mapping in structured samples.CrossRef |

Zhao FP, McParland S, Kearney F, Du LX, Berry DP (2015) Detection of selection signatures in dairy and beef cattle using high-density genomic information. Genetics, Selection, Evolution. 47, 49
Detection of selection signatures in dairy and beef cattle using high-density genomic information.CrossRef |

Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL (2009) A whole-genome assembly of the domestic cow, Bos taurus. Genome Biology 10,
A whole-genome assembly of the domestic cow, Bos taurus.CrossRef | 1:CAS:528:DC%2BD1MXlslaksbk%3D&md5=9f4a77d70b112e68f5d5643712bfe95aCAS |



Supplementary MaterialSupplementary Material (176 KB) Export Citation