An Efficient Synthesis of 5,5′-(Tetradecane-1,14-diyl)bis(2-methylbenzene-1,3-diol) and Related Substances

Abstract

An efficient and versatile method was developed to synthesize 5,5′-(tetradecane-1,14-diyl)bis(2-methylbenzene-1,3-diol) (striatol), a minor component of the plant Grevillea striata (Proteaceae family). Other substances prepared in high yield by the method include 5,5′-(dodecane-1,12-diyl)bis(2-methylbenzene-1,3-diol), 5,5′-(decane-1,10-diyl)bis(2-methylbenzene-1,3-diol), 5,5′-(octane-1,8-diyl)bis(2-methylbenzene-1,3-diol) and 2-methyl-5-nonylresorcinol