Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science

Reactions of Ethyl Indole-2-carboxylate in Aqueous Media at High Temperature

Christopher R. Strauss and Robert W. Trainor

Australian Journal of Chemistry 51(8) 703 - 706
Published: 1998


Direct, preparative methods utilizing high-temperature aqueous media were developed for indole and indole-2-carboxylic acid from ethyl indole-2-carboxylate. Yields were excellent for these reactions, which were carried out in 1 h or less, at temperatures up to 270°C, in a microwave batch reactor of the authors" design. Avoidance of undesirable copper salts, high-boiling organic bases and heat-transfer oils made the methods environmentally benign.

© CSIRO 1998

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