Asymmetric Syntheses of Isochroman-4,7-diols Through Intramolecular Cyclization of Tethered Lactaldehydes.
Robin G. F. Giles, Ivan R. Green, Yolanta Gruchlik and Francois J. Oosthuizen
Australian Journal of Chemistry
53(4) 341 - 347
Published: 2000
Abstract
Ready cyclization through silica gel chromatography of the asymmetric phenolic lactaldehyde (14) afforded the diastereomeric pair of isochroman-4,7-diols (21) and (23) in good yield, while (17), the benzylic epimer of (14), similarly yielded the isochroman-4,7-diol (25) as a single diastereomer.Keywords: Asymmetric synthesis; isochromandiols; lactaldehyde cyclization.
https://doi.org/10.1071/CH00020
© CSIRO 2000
