Pigments of Fungi. LXIX. Total Synthesis of (R)-Ochratoxin α and the Formal Total Synthesis of Ochratoxin

Abstract

(R)-Ochratoxin α, the monochiral carboxylic acid component of the biologically active dipeptide ochratoxin A, is synthesized for the first time over nine steps from (R)-propylene oxide. The method constitutes a versatile and general route to functionalized dihydroisocoumarins.