Solution-Phase Synthesis of Linear and Cyclic Peptidomimetics Based on 2-Aminoalkyloxazole-4- or -5-carboxylates

Matthew O. Cox; Rolf H. Prager; Carina E. Svensson

doi:10.1071/CH03250

RESEARCH ARTICLE

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Solution-Phase Synthesis of Linear and Cyclic Peptidomimetics Based on 2-Aminoalkyloxazole-4- or -5-carboxylates

Matthew O. Cox ^A , Rolf H. Prager ^A ^B and Carina E. Svensson ^A

+ Author Affiliations

- Author Affiliations

^A School of Chemistry, Physics and Earth Sciences, Flinders University of South Australia, Adelaide SA 5001, Australia.

^B Author to whom correspondence should be addressed (e-mail: rolf.prager@flinders.edu.au).

Australian Journal of Chemistry 57(8) 747-758 https://doi.org/10.1071/CH03250
Submitted: 19 September 2003 Accepted: 17 November 2003 Published: 10 August 2004

Abstract

The solution-phase synthesis of several small linear and cyclic peptidomimetics based on the coupling of BOC-protected 2-aminoalkyloxazole-4- or -5-carboxylic acids is reported. Cyclic amides have been formed both by sequential coupling and cyclization, or by cyclooligomerization.

Acknowledgments

M.O.C. acknowledges the award of a Flinders University research scholarship, and C.E.S. is grateful for the award of an OPRS scholarship from Flinders University. We are grateful for financial support from the Australian Research Council.

References

Solution-Phase Synthesis of Linear and Cyclic Peptidomimetics Based on 2-Aminoalkyloxazole-4- or -5-carboxylates

Abstract

Acknowledgments

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