Register      Login
Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Shopping Cart: ( empty )
You are here: Home > Journals > CH > CH05027
RESEARCH ARTICLE
Contents Vol 58(6)

Vitamin B12 Release from P(HEMA-co-THFMA) in Water and SBF: A Model Drug Release Study*

Mohammad A. Chowdhury A , David J. T. Hill A C and Andrew K. Whittaker B
+ Author Affiliations
- Author Affiliations

A Polymer Materials and Radiation Group, Department of Chemistry, University of Queensland, Brisbane QLD 4072, Australia.

B Centre for Magnetic Resonance, University of Queensland, Brisbane QLD 4072, Australia.

C Corresponding author. Email: d.hill@uq.edu.au

Australian Journal of Chemistry 58(6) 451-456 https://doi.org/10.1071/CH05027
Submitted: 16 January 2005  Accepted: 18 April 2005   Published: 14 June 2005

Abstract

A model drug release study on the ingress of water and Kokubo simulated body fluid (SBF) into poly(2-hydroxyethyl methacrylate) (P(HEMA)) and its copolymers with tetrahydrofurfuryl methacrylate (THFMA) loaded with vitamin B12 was undertaken over the temperature range 298–318 K. The polymers were studied as cylinders and were loaded with either 5 or 10 wt-% of the drug. The drug release from the polymers was found to follow a Fickian diffusion mechanism in the early stages of the drug release, with higher normalized release rates at higher temperatures and higher drug loadings. The normalized release rates were also found to be higher for the SBF solution than for water. The copolymer composition was found to have a significant effect on the rate of release of the drug, with the rate falling rapidly between HEMA mole fractions of 1.0 and 0.8, but for lower mole fractions of HEMA the normalized release rate decreased more slowly. This behaviour followed the trend found for the changes in the equilibrium penetrant contents for the copolymers.


The authors which to acknowledge the financial support for this work from the Australian Research Council.


References


[1]   N. A. Peppas, H. J. Moynihan, in Hydrogels in Medicine and Pharmacy (Ed. N. A. Peppas) 1987, Vol. II, p. 49 (CRC Press: Boca Raton, FL).

[2]   N. A. Peppas, A. R. Khare, Adv. Drug Deliv. Rev. 1993, 11,  1.
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
         
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |   in press.
         
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  open url image1

[27]   [27] H. P. S. Swai, Ph.D. Thesis 2000 (University of London: London).




* This paper is dedicated to Professor David Solomon on the occasion of his 75th birthday.