Novel 5-(3-(Substituted)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl Derivatives: Synthesis and Anticancer Activity
Xin-Hua Liu A D , Bao-An Song C , Pinaki S. Bhadury C , Hai-Liang Zhu A B , Ping Cui A , Ke-Ke Hou C and Hong-Li Xu AA Key Laboratory of Anhui Educational Department, Anhui University of Technology, Maanshan, 243002, China.
B State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.
C Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang, 55002, China.
D Corresponding author. Email: zlp@ahut.edu.cn
Australian Journal of Chemistry 61(11) 864-869 https://doi.org/10.1071/CH07395
Submitted: 16 November 2007 Accepted: 16 April 2008 Published: 5 November 2008
Abstract
Thirty novel 5-(3-(substituted phenyl)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl derivatives were synthesized and evaluated for their antitumour activity. The bioassays showed that the 2-fluorobenzoyl derivative 6ai, the 4-trifluoromethylbenzoyl derivative 6ah, and the 3-trifluoromethyl isoxazole derivatives (6ch and 6ci) were highly effective against PC-3 cells. The IC50 values of 6ah and 6ai against PC-3 cells were 1.5 and 1.8 μg mL–1, respectively.
Acknowledgements
The authors thank the Anhui Natural Science Foundation, Anhui Province (Grant no. 070416274X) for providing financial support for the project and to thank the Student Research Train Project of Anhui Technology University (no. 08021). The work was also supported by the opening foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, grant no. 2008GDGP0105.
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