Synthesis, Characterization, and DNA Binding Studies of Ruthenium(ii) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

Yi-Xian Yuan; Yi-Can Wang; Long Jiang; Feng Gao; Si-Min Liang; Cheng-Yong Su; Hui Chao; Liang-Nian Ji

doi:10.1071/CH08127

RESEARCH ARTICLE

Synthesis, Characterization, and DNA Binding Studies of Ruthenium(ii) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

Yi-Xian Yuan ^A , Yi-Can Wang ^A , Long Jiang ^A , Feng Gao ^A , Si-Min Liang ^A , Cheng-Yong Su ^A , Hui Chao ^A ^B and Liang-Nian Ji ^A ^B

+ Author Affiliations

- Author Affiliations

^A MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

^B Corresponding authors. Email: ceschh@mail.sysu.edu.cn, cesjln@mail.sysu.edu.cn

Australian Journal of Chemistry 61(9) 732-739 https://doi.org/10.1071/CH08127
Submitted: 29 March 2008 Accepted: 23 July 2008 Published: 5 September 2008

Abstract

Three novel asymmetric ruthenium(ii) complexes, [Ru(bpy)₂(PAIDH)]²⁺ 1, [Ru(phen)₂(PAIDH)]²⁺ 2, and [Ru(dmp)₂(PAIDH)]²⁺ 3 (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, PAIDH = 2-pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione), have been synthesized and characterized. The structure of the deprotonated complex [Ru(dmp)₂(PAID)]⁺ 4 has been determined by single-crystal X-ray diffraction techniques, and the anthraquinone moiety is approximately coplanar with the imidazole ring. The DNA binding properities of complexes 1, 2, and 3 to calf-thymus DNA (CT-DNA) were investigated. Spectroscopic studies and viscosity experiments suggest that the Ru^II complexes intercalate into DNA base pairs by the extended anthraquinone unit, and the ancillary ligands have significant effects on the spectroscopic properties and DNA binding behaviour of the Ru^II complexes.

Acknowledgements

We gratefully acknowledge the supports of the 973 Program, the National Natural Science Foundation of China, the Program for New Century Excellent Talents in University, the Key Project, and the Scientific Research Foundation for the Returned Overseas Chinese Scholars of Ministry of Education.

References

Synthesis, Characterization, and DNA Binding Studies of Ruthenium(ii) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

Abstract

Acknowledgements

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