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RESEARCH FRONT
Contents Vol 61(9)

Drug Delivery Devices and Targeting Agents for Platinum(ii) Anticancer Complexes

Anwen M. Krause-Heuer A , Maxine P. Grant A , Nikita Orkey A and Janice R. Aldrich-Wright A B
+ Author Affiliations
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A School of Biomedical and Health Sciences, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia.

B Corresponding author. Email: j.aldrich-wright@uws.edu.au

Australian Journal of Chemistry 61(9) 675-681 https://doi.org/10.1071/CH08157
Submitted: 16 April 2008  Accepted: 12 June 2008   Published: 5 September 2008

Abstract

An ideal platinum-based delivery device would be one that selectively targets cancerous cells, can be systemically delivered, and is non-toxic to normal cells. It would be beneficial to provide drug delivery devices for platinum-based anticancer agents that exhibit high drug transport capacity, good water solubility, stability during storage, reduced toxicity, and enhanced anticancer activity in vivo. However, the challenges for developing drug delivery devices include carrier stability in vivo, the method by which extracellular or intracellular drug release is achieved, overcoming the various mechanisms of cell resistance to drugs, controlled drug release to cancer cells, and platinum drug bioavailability. There are many potential candidates under investigation including cucurbit[n]urils, cyclodextrins, calix[n]arenes, and dendrimers, with the most promising being those that are synthetically adaptable enough to attach to targeting agents.


Acknowledgements

A. M. Krause-Heuer, M. P. Grant, and N. Orkey were supported by University of Western Sydney Postgraduate Awards. A. M. Krause-Heuer was also supported by a University of Western Sydney Vice Chancellor’s Leadership Scholarship, and A. M. Krause-Heuer and N. Orkey were also supported by College of Health and Science Publication Fellowships.


References


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