Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Synthesis, Structure, and Selective Cytotoxicity of Organometallic Cp*RuII O-Alkyl-N-phenylcarbamate Sandwich Complexes

Bradley T. Loughrey A , Michael L. Williams A , Thomas J. Carruthers A , Peter G. Parsons B and Peter C. Healy A C
+ Author Affiliations
- Author Affiliations

A Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Qld 4111, Australia.

B Drug Discovery Group, Queensland Institute of Medical Research, Brisbane, Qld 4029, Australia.

C Corresponding author. Email: p.healy@griffith.edu.au

Australian Journal of Chemistry 63(2) 245-251 https://doi.org/10.1071/CH09420
Submitted: 31 July 2009  Accepted: 4 November 2009   Published: 26 February 2010

Abstract

Tetraphenylborate salts of the η6-arene Cp*RuII O-alkyl-N-phenyl carbamate organometallic sandwich complexes, [Cp*Ru(PhNHCO2R)]BPh4 for R = Me (1), Et (2), and n-Pr (3), have been prepared by a facile one-pot reaction between ruthenium trichloride, pentamethylcyclopentadiene, and phenylisocyanate in refluxing alcohol solutions, and have been characterized by Fourier-transform IR and NMR spectroscopy, electrospray mass spectrometry, and single-crystal X-ray structure determinations. In vitro cytotoxicity studies show the complexes to be potent growth inhibitors for a range of tumour cell lines, while expressing significantly lower levels of toxicity towards a normal human fibroblast cell line.


Acknowledgements

We thank Griffith University, the Queensland University of Technology and the Eskitis Institute for Cell and Molecular Therapies for support of this work.


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