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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
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PEGylated Gold Nanoparticles Functionalized with β-Cyclodextrin Inclusion Complexes: Towards Metal Nanoparticle–Polymer–Carbohydrate Cluster Biohybrid Materials

Jingquan Liu A B , Eki Setijadi A , Yingkai Liu A , Michael R. Whittaker A , Cyrille Boyer A and Thomas P. Davis A B
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A Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.

B Corresponding authors. Email: jingquan.liu@unsw.edu.au, t.davis@unsw.edu.au

Australian Journal of Chemistry 63(8) 1245-1250 https://doi.org/10.1071/CH10091
Submitted: 18 February 2010  Accepted: 23 June 2010   Published: 10 August 2010

Abstract

A cholesterol-functional trithiocarbonate reversible addition–fragmentation chain transfer (RAFT) agent was synthesized and employed to generate well-defined poly(polyethylene glycol) acrylate with cholesterol chain termini using RAFT polymerization. Subsequently, the polymers were grafted onto the surface of gold nanoparticles using the trithiocarbonate functionality to bind to the gold surface. The cholesterol moieties were then modified via complexation with β-cyclodextrin. The step-by-step modification of gold nanoparticles was characterized by dynamic light scattering, attenuated total reflection infrared spectroscopy and surface plasmon resonance analysis.


Acknowledgements

T.P.D. thanks the Australian Research Council for a Federation Fellowship Award. J.L. acknowledges the UNSW Vice Chancellor’s Post-doctoral Research Fellowship.


References


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