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RESEARCH ARTICLE
Contents Vol 64(11)

Direct C–O Bond Activation Mediated by AcOH: A New Metal-Free Way for α-Functionalization of Ferrocene Alcohols

Ran Jiang A , Xue-Qiang Chu A , Xiao-Ping Xu A , Bin Wu A and Shun-Jun Ji A B
+ Author Affiliations
- Author Affiliations

A Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.

B Corresponding author. Email: chemjsj@suda.edu.cn

Australian Journal of Chemistry 64(11) 1530-1537 https://doi.org/10.1071/CH11167
Submitted: 28 April 2011  Accepted: 10 August 2011   Published: 16 November 2011

Abstract

α-functionalization of ferrocenyl alcohols by direct C–O bond activation by indoles, active methylene compounds, electron-rich arenes, anilines, alcohols, and thiols in acetic acid is described. This protocol provides a relatively green and efficient combinatorial access to ferrocene derivatives in a metal-free manner.


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