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RESEARCH ARTICLE
Contents Vol 65(2)

Synthesis, Anti-Arthritic, and Anti-Inflammatory Activity of N-Tosyl aza Cyclophanes

Perumal Rajakumar A C and Ramar Padmanabhan B
+ Author Affiliations
- Author Affiliations

A Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai – 600 025, India.

B Research and Development Centre, Orchid Chemicals and Pharmaceuticals Ltd, Sozhanganallur, Chennai – 600 119, India.

C Corresponding author. Email: perumalrajakumar@gmail.com

Australian Journal of Chemistry 65(2) 186-192 https://doi.org/10.1071/CH11435
Submitted: 13 November 2011  Accepted: 9 January 2012   Published: 1 February 2012

Abstract

The synthesis of novel N-tosyl tetraaza cyclophanes and N-tosyl diaza cyclophane incorporating m-terphenyl as spacer units is described. Anti-arthritic activity was studied by inhibition of the protein denaturation method (bovine serum albumin). All the N-tosyl aza cyclophanes exhibit excellent anti-arthritic activity. Anti-inflammatory activity of the synthesized cyclophanes was investigated using the human red blood cells (HRBC) membrane stabilization method and some of the N-tosyl aza cyclophanes exhibited good anti-inflammatory activity.


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