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RESEARCH ARTICLE
Contents Vol 66(10)

The Fifth Element in Drug Design: Boron in Medicinal Chemistry

Jan Kahlert A , Christopher J. D. Austin A , Michael Kassiou A and Louis M. Rendina A B
+ Author Affiliations
- Author Affiliations

A School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

B Corresponding author. Email: lou.rendina@sydney.edu.au

Australian Journal of Chemistry 66(10) 1118-1123 https://doi.org/10.1071/CH13256
Submitted: 15 May 2013  Accepted: 4 June 2013   Published: 15 July 2013

Abstract

The unique chemistry of boron allows for the utilisation of novel building-blocks which are not traditionally found in medicinal chemistry. The pharmaceutical industry has begun to exploit boronic acid derivatives as new drugs and several research groups are also exploring 1,2-azaborines and icosahedral boranes known as carboranes as boron-based structural motifs, with great promise for innovative drug design. Recent advances in the medicinal chemistry of these three important boron moieties are highlighted and illustrated with selected examples.


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