Lanthanide-Based Polymers with Charged Ligand Backbones: Triple-Stranded Chain Structures and their DNA Cleavage Studies
Ming Chen A , Xiao-Yan Tang B , Ming-Zhen Chen A , Jin-Xiang Chen A C and Wen-Hua Chen A C
+ Author Affiliations
- Author Affiliations
A School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
B Department of Chemistry and Materials Engineering, Jiangsu Key Laboratory of Advanced Functional Materials, Changshu Institute of Technology, Changshu 215500, Jiangsu, China.
C Corresponding author. Email: jxchen@smu.edu.cn, whchen@smu.edu.cn
Australian Journal of Chemistry 68(3) 493-499 https://doi.org/10.1071/CH14025
Submitted: 7 March 2014 Accepted: 1 July 2014 Published: 22 September 2014
Abstract
Four rare-earth metal complexes, [Ln(Ccbp)3(H2O)3]n (Ln = La (1), Ce (2), Pr (3) and Nd (4)) are synthesised from the ligand H2CcbpBr (H2CcbpBr = 4-carboxy-1-(4-carboxybenzyl)pyridinium bromide) and the respective lanthanide metal ions. Complexes 1–4 are isostructural in that every three Ccbp– ligands juxtapose two Ln3+ ions in a monodentate coordination mode to form triple-stranded one-dimensional chain structures. Each central Ln3+ atom further associates with three H2O molecules, furnishing a monocapped square-antiprism geometry. Agarose gel electrophoresis studies indicate that 1–4 are capable of cleaving DNA in the presence of H2O2, most probably via an oxidative cleavage mechanism. Complexes 1 and 2 exhibited catalytic efficiencies (kmax/KM) of 37.69 and 34.11 h–1 mM–1, and are approx. 15- and 20-fold more effective than those of complexes 3 (kmax/KM = 1.75 h–1 mM–1) and 4 (kmax/KM = 2.21 h–1 mM–1).
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