Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Ethanolic RAFT Dispersion Polymerization of 2-(Naphthalen-2-yloxy)ethyl Methacrylate and 2-Phenoxyethyl Methacrylate with Poly[2-(dimethylamino)ethyl Methacrylate] Macro-Chain Transfer Agents

Yiwen Pei A B , Nadia C. Dharsana A and Andrew B. Lowe A B C
+ Author Affiliations
- Author Affiliations

A School of Chemical Engineering, Centre for Advanced Macromolecular Design, University of New South Wales, Kensington, Sydney, NSW 2052, Australia.

B Current address: Nanochemistry Research Institute (NRI) & Department of Chemistry, Curtin University, Bentley Campus, Bentley, Perth, WA 6102, Australia.

C Corresponding author. Email: a.lowe@unsw.edu.au

Australian Journal of Chemistry 68(6) 939-945 https://doi.org/10.1071/CH14490
Submitted: 5 August 2014  Accepted: 7 September 2014   Published: 9 December 2014

Abstract

The ethanolic reversible addition-fragmentation chain transfer dispersion polymerization (RAFTDP), at 21 wt-%, of 2-(naphthalen-2-yloxy)ethyl methacrylate (NOEMA) and 2-phenoxyethyl methacrylate (POEMA) with a poly[2-(dimethylamino)ethyl methacrylate] macro-chain transfer agent (CTA) with an average degree of polymerization of 20 (PDMAEMA20) is described. DMAEMA20-b-NOEMAy (y = 20–125) block copolymers were readily prepared under dispersion conditions in ethanol at 70°C. However, the polymerization of NOEMA was not well controlled, with size exclusion chromatograms being distinctly bi or multimodal with measured dispersities CH14490_IE1.gif. Though NOEMA copolymerization was not ideal, the resulting series of block copolymers did exhibit the anticipated full spectrum of nanoparticle morphologies (spheres, worms, and vesicles). Interestingly, these morphology transitions occurred over a relatively narrow range of block copolymer compositions. In the case of POEMA, copolymerization was also poorly controlled with 1.50 ≤ ĐM ≤ 1.83 for the series of DMAEMA20-b-POEMAy copolymers. In contrast to the NOEMA-based copolymers, the POEMA series only yielded nanoparticles with a spherical morphology whose size increased with increasing average degrees of polymerization of the POEMA block. Collectively, though both NOEMA and POEMA can be utilized in ethanolic RAFT dispersion polymerization formulations, these preliminary studies suggest that neither appears to be an ideal aryl methacrylate choice as comonomer, especially if the goal is to combine the synthesis of well-defined copolymers with efficient nanoparticle formation.


References

[1]  Y. Mai, A. Eisenberg, Chem. Soc. Rev. 2012, 41, 5969.
         | CrossRef | 1:CAS:528:DC%2BC38Xht1aqsbvL&md5=fb736bd50a6b1f97fe03068c0d0939a8CAS | 22776960PubMed |

[2]  G. Riess, Prog. Polym. Sci. 2003, 28, 1107.
         | CrossRef | 1:CAS:528:DC%2BD3sXjvVCnsbw%3D&md5=a878f8e3326f99a54bdb8ae6b12a790aCAS |

[3]  D. E. Discher, A. Eisenberg, Science 2002, 297, 967.
         | CrossRef | 1:CAS:528:DC%2BD38Xmt1Clsbs%3D&md5=337e2102f73ac14be73a0fcfd5df9be9CAS | 12169723PubMed |

[4]  T. Nicolai, O. Colombani, C. Chassenieux, Soft Matter 2010, 6, 3111.
         | CrossRef | 1:CAS:528:DC%2BC3cXotlyktrs%3D&md5=797b74ee071b060040afce108a626ca2CAS |

[5]  S. J. Holder, N. A. J. M. Sommerdijk, Polym. Chem. 2011, 2, 1018.
         | CrossRef | 1:CAS:528:DC%2BC3MXltF2rtLw%3D&md5=eb03b6b2009ae340ac2f0ccbef52a1a4CAS |

[6]  E. B. Zhulina, O. V. Borisov, Macromolecules 2012, 45, 4429.
         | CrossRef | 1:CAS:528:DC%2BC38XmsVGlsr4%3D&md5=13c223e043dacdf3084824f3bef38337CAS |

[7]  L. Jia, D. Lévy, D. Durand, M. Impéror-Clec, A. Cao, M.-H. Li, Soft Matter 2011, 7, 7395.
         | CrossRef | 1:CAS:528:DC%2BC3MXps1Wnurc%3D&md5=6300833c73c79191a928a7db94377a6cCAS |

[8]  B. Yu, A. B. Lowe, K. Ishihara, Biomacromolecules 2009, 10, 950.
         | CrossRef | 1:CAS:528:DC%2BD1MXitlSmsLs%3D&md5=eb6e78e1824f743ffd8b43a98fcc31e6CAS | 19243090PubMed |

[9]  P. J. Roth, T. P. Davis, A. B. Lowe, Polym. Chem. 2012, 3, 2228.
         | CrossRef | 1:CAS:528:DC%2BC38Xps1Sqsbc%3D&md5=c30c3b0ee815d884a2d3b85cc147231fCAS |

[10]  P. J. Roth, T. P. Davis, A. B. Lowe, Macromolecules 2012, 45, 3221.
         | CrossRef | 1:CAS:528:DC%2BC38XkvVKmsbw%3D&md5=1dcbe80dabf63db071c2539791cb80fbCAS |

[11]  D. Roy, W. L. A. Brooks, B. S. Sumerlin, Chem. Soc. Rev. 2013, 42, 7214.
         | CrossRef | 1:CAS:528:DC%2BC3sXht1WisbzF&md5=fd1456e6c41f24a7dc80653bd308780cCAS | 23450220PubMed |

[12]  Y. Mitsukami, A. Hashidzume, S.-I. Yusa, Y. Morishima, A. B. Lowe, C. L. McCormick, Polymer 2006, 47, 4333.
         | CrossRef | 1:CAS:528:DC%2BD28Xlt12luro%3D&md5=56601937d862cc0e414786476a7adcecCAS |

[13]  J. Y. Quek, P. J. Roth, R. A. Evans, T. P. Davis, A. B. Lowe, J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 394.
         | CrossRef | 1:CAS:528:DC%2BC38XhsFOmtbzP&md5=e206a8a167eba9e1bf5d22e67bfe0210CAS |

[14]  A. B. Lowe, E. Wang, V. Tiriveedhi, P. Butko, C. L. McCormick, Macromol. Chem. Phys. 2007, 208, 2339.
         | CrossRef | 1:CAS:528:DC%2BD2sXhtlOnsrnN&md5=75b430c606a63a2cbb0d4106f04290beCAS |

[15]  S. Dai, P. Ravi, K. C. Tam, Soft Matter 2008, 4, 435.
         | CrossRef | 1:CAS:528:DC%2BD1cXitlCisr8%3D&md5=0fcc0d4f74135533e7f53d1170c4595cCAS |

[16]  P. J. Roth, J. Y. Quek, Y. Zhu, B. M. Blunden, A. B. Lowe, Chem. Commun. 2014, 50, 9561.
         | CrossRef | 1:CAS:528:DC%2BC2cXhtFSgtLvL&md5=666f352993696615eeae7737d310783bCAS |

[17]  Z. Tuzar, H. Pospisil, J. Plestil, A. B. Lowe, F. L. Baines, N. C. Billingham, S. P. Armes, Macromolecules 1997, 30, 2509.
         | CrossRef | 1:CAS:528:DyaK2sXitFymtL0%3D&md5=515c11f4e66a1204c6ab581813c3bbf1CAS |

[18]  D. A. Rankin, A. B. Lowe, Macromolecules 2008, 41, 614.
         | CrossRef | 1:CAS:528:DC%2BD1cXhsFKiug%3D%3D&md5=70a1784313614e76dd652707a23e39fdCAS |

[19]  K. Yao, C. Tang, J. Zhang, C. Bunyard, Polym. Chem. 2013, 4, 528.
         | CrossRef | 1:CAS:528:DC%2BC3sXjtl2muw%3D%3D&md5=4468104c8fe1d9f0732c8880d67461fbCAS |

[20]  A. B. Lowe, N. C. Billingham, S. P. Armes, Macromolecules 1999, 32, 2141.
         | CrossRef | 1:CAS:528:DyaK1MXhslKhur0%3D&md5=57194b2243d1a841243424d04339e6c7CAS |

[21]  D. Wang, T. Wu, X. Wan, X. Wang, S. Liu, Langmuir 2007, 23, 11866.
         | CrossRef | 1:CAS:528:DC%2BD2sXhtFCisLjE&md5=8ec7b164647f8b34bc133a3ebbd94909CAS | 17929848PubMed |

[22]  A. B. Lowe, C. L. McCormick, Chem. Rev. 2002, 102, 4177.
         | CrossRef | 1:CAS:528:DC%2BD38XotFSrur8%3D&md5=3c0fbfbc5cb6b3862b043b2ba86faa68CAS | 12428987PubMed |

[23]  M. S. Donovan, A. B. Lowe, T. A. Sanford, C. L. McCormick, J. Polym. Sci., Part A: Polym. Chem. 2003, 41, 1262.
         | CrossRef | 1:CAS:528:DC%2BD3sXivFCnt7k%3D&md5=e6cdc5110936c12f0bfbf45440b11324CAS |

[24]  Y. Pei, N. C. Dharsana, J. A. van Hensbergen, R. P. Burford, P. J. Roth, A. B. Lowe, Soft Matter 2014, 10, 5787.
         | CrossRef | 1:CAS:528:DC%2BC2cXhtVKrsLrJ&md5=96afe854d09de66550b70b914aac084dCAS | 24975501PubMed |

[25]  S. Abbas, Z. Li, H. Hassan, T. P. Lodge, Macromolecules 2007, 40, 4048.
         | CrossRef | 1:CAS:528:DC%2BD2sXks12ms7Y%3D&md5=a2b133e7f6a67fd2f4454c37d93148b8CAS |

[26]  I. LaRue, M. Adam, M. Pitsikalis, N. Hadjichristdis, M. Rubenstein, S. S. Sheiko, Macromolecules 2006, 39, 309.
         | CrossRef | 1:CAS:528:DC%2BD2MXht1aku7nE&md5=42fb867a297a36cc5eabe15ead3b04cdCAS |

[27]  Y. Pei, A. B. Lowe, Polym. Chem. 2014, 5, 2342.
         | CrossRef | 1:CAS:528:DC%2BC2cXjslGmsb0%3D&md5=a9f605257192852c6a03a888368e0231CAS |

[28]  D. Zehm, L. P. D. Ratcliffe, S. P. Armes, Macromolecules 2013, 46, 128.
         | CrossRef | 1:CAS:528:DC%2BC38XhvVersL7F&md5=6003ef9791ac53993a834aa1265e3c9dCAS |

[29]  S. Sugihara, A. Blanazs, S. P. Armes, A. J. Ryan, A. L. Lewis, J. Am. Chem. Soc. 2011, 133, 15707.
         | CrossRef | 1:CAS:528:DC%2BC3MXhtFCgsL%2FJ&md5=ed3ab1011a6ec242c49665d819ffcf36CAS | 21854065PubMed |

[30]  M. Semsarilar, V. Ladmiral, A. Blanazs, S. P. Armes, Langmuir 2013, 29, 7416.
         | CrossRef | 1:CAS:528:DC%2BC38XhslOmu73F&md5=d285a4b49182246f07355be8fb29f29bCAS | 23205729PubMed |

[31]  M. Semsarilar, E. R. Jones, A. Blanazs, S. P. Armes, Adv. Mater. 2012, 24, 3378.
         | CrossRef | 1:CAS:528:DC%2BC38XntlSnurY%3D&md5=6a5c7164bcfa48ddd9789472060bb667CAS | 22605479PubMed |

[32]  V. Ladmiral, M. Semsarilar, I. Canton, S. P. Armes, J. Am. Chem. Soc. 2013, 135, 13574.
         | CrossRef | 1:CAS:528:DC%2BC3sXht1OjtbvM&md5=798583b1dd61b302bee598559b811e57CAS | 23941545PubMed |

[33]  L. A. Fielding, M. J. Derry, V. Ladmiral, J. Rosselgong, A. M. Rodrigues, L. P. D. Ratcliffe, S. Sugihara, S. P. Armes, Chem. Sci. 2013, 4, 2081.
         | CrossRef | 1:CAS:528:DC%2BC3sXltVOltrs%3D&md5=414c9779b9773223701e68197ea7044dCAS |

[34]  A. Blanazs, A. J. Ryan, S. P. Armes, Macromolecules 2012, 45, 5099.
         | CrossRef | 1:CAS:528:DC%2BC38XosFemtrc%3D&md5=b0ea68b796701ee0e8623fc09cc72a1eCAS |

[35]  J.-T. Sun, C.-Y. Hong, C.-Y. Pan, Polym. Chem. 2013, 4, 873.
         | CrossRef | 1:CAS:528:DC%2BC3sXhtlelt7g%3D&md5=d67356b30e1f49714dcad5e5ab676d71CAS |

[36]  W. M. Wan, X. L. Sun, C. Y. Pan, Macromol. Rapid Commun. 2010, 31, 399.
         | CrossRef | 1:CAS:528:DC%2BC3cXitFejt7k%3D&md5=849fd602cf810fb125aec23f7ad556cfCAS | 21590920PubMed |

[37]  W.-M. Wan, C.-Y. Pan, Polym. Chem. 2010, 1, 1475.
         | CrossRef | 1:CAS:528:DC%2BC3cXhtl2msLbO&md5=d18bb37337bdf18c14111d9e05cbbef7CAS |

[38]  W.-D. He, X.-L. Sun, W.-M. Wan, C.-Y. Pan, Macromolecules 2011, 44, 3358.
         | CrossRef | 1:CAS:528:DC%2BC3MXksFarsb8%3D&md5=f7a910f5938ca329bcab6fccaa1b8bacCAS |

[39]  C.-Q. Huang, C.-Y. Pan, Polymer 2010, 51, 5115.
         | CrossRef | 1:CAS:528:DC%2BC3cXhtlSgtrvO&md5=7fb77f46a289a4c17d7ebb33b14f4337CAS |

[40]  J. Jennings, M. Beija, J. T. Kennon, H. Willcock, R. K. O’Reilly, S. Rimmer, S. M. Howdle, Macromolecules 2013, 46, 6843.
         | CrossRef | 1:CAS:528:DC%2BC3sXhtlCht7fP&md5=26107305c2ee331509024255f761f09cCAS |

[41]  M. Zong, K. J. Thurecht, S. M. Howdle, Chem. Commun. 2008, 5942.
         | CrossRef | 1:CAS:528:DC%2BD1cXhsVSqtbzP&md5=bbc2786db8931ccecd63141962852638CAS |

[42]  L. Houillot, C. Bui, C. Farcet, C. Moire, J. A. Raust, H. Pasch, M. Save, B. Charleux, ACS Appl. Mater. Interfaces 2010, 2, 434.
         | CrossRef | 1:CAS:528:DC%2BC3cXnt1Sgsw%3D%3D&md5=aba80a903691a523f0b126af964a96e5CAS | 20356189PubMed |

[43]  J. Rieger, C. Grazon, B. Charleux, D. Alaimo, C. Jérôme, J. Polym. Sci., Part A: Polym. Chem. 2009, 47, 2373.
         | CrossRef | 1:CAS:528:DC%2BD1MXltVOjsb4%3D&md5=2341a06a10ec57f3ff80b3f55df3dd13CAS |

[44]  M. J. Warren, S. P. Armes, J. Am. Chem. Soc. 2014, 136, 10174.
         | CrossRef | 1:CAS:528:DC%2BC2cXhtVGlu7bM&md5=8124122cdf51b170b02602db9d498bb7CAS |

[45]  R. Verber, A. Blanazs, S. P. Armes, Soft Matter 2012, 8, 9915.
         | CrossRef | 1:CAS:528:DC%2BC38XhtlekurnK&md5=0390be1d7bb01a5b1ea9168e117c10d3CAS |

[46]  A. Blanazs, R. Verber, O. O. Mykhaylyk, A. J. Ryan, J. Z. Heath, C. W. I. Doudlas, S. P. Armes, J. Am. Chem. Soc. 2012, 134, 9741.
         | CrossRef | 1:CAS:528:DC%2BC38XmvFWqs7o%3D&md5=8c99629f1770de7d692622e35912ffacCAS | 22582795PubMed |

[47]  S. H. Thang, Y. K. Chong, R. T. A. Mayadunne, G. Moad, E. Rizzardo, Tetrahedron Lett. 1999, 40, 2435.
         | CrossRef | 1:CAS:528:DyaK1MXhvVeksL0%3D&md5=263e75731636d684fffcb2f471fd78b2CAS |

[48]  P. Chambon, A. Blanazs, G. Battaglia, S. P. Armes, Macromolecules 2012, 45, 5081.
         | CrossRef | 1:CAS:528:DC%2BC38XotlSnurc%3D&md5=f07cc8767ba319df35a606b70d735c8fCAS |

[49]  L. P. D. Ratcliffe, A. Blanazs, C. N. Williams, S. L. Brown, S. P. Armes, Polym. Chem. 2014, 5, 3643.
         | CrossRef | 1:CAS:528:DC%2BC2cXns1Wju7c%3D&md5=691179b52ec342164cac82521dcddf40CAS |

[50]  T. Pal, T. K. Gosh, A. Pal, Indian J. Chem. 2001, 40B, 850.
         | 1:CAS:528:DC%2BD3MXntlSjt7s%3D&md5=a689b1996c21480b235cebd85f88d5d4CAS |

[51]  H. Maeda, T. Maeda, K. Mizuno, Molecules 2012, 17, 5108.
         | CrossRef | 1:CAS:528:DC%2BC38XnvFWls70%3D&md5=0e907f691df8bab18b41928339d442d4CAS | 22555299PubMed |

[52]  G. Weber, F. J. Farris, Biochemistry 1979, 18, 3075.
         | CrossRef | 1:CAS:528:DyaE1MXkslWiurk%3D&md5=f6f60f9f1c7d822112e966babf07f77cCAS | 465454PubMed |

[53]  W. Yuan, J. Yuan, M. Zhou, C. Pan, J. Polym. Sci., Part A: Polym. Chem. 2008, 46, 2788.
         | CrossRef | 1:CAS:528:DC%2BD1cXltVOiurs%3D&md5=fa820c901ac45626fb05ab8991db21d4CAS |

[54]  R. D. Stramel, C. Nguyen, S. E. Webber, M. A. J. Rodgers, J. Phys. Chem. 1988, 92, 2934.
         | CrossRef |

[55]  S. Meuer, L. Braun, R. Zentel, Macromol. Chem. Phys. 2009, 210, 1528.
         | CrossRef | 1:CAS:528:DC%2BD1MXhtFGktrbO&md5=98d10e95359f20f59b30f6e429e87896CAS |



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