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RESEARCH ARTICLE
Contents Vol 69(2)

Controlled Delivery of Levothyroxine Using Porous Silicon as a Drug Nanocontainer

Soheila Kashanian A D , Elham Rostami B , Frances J. Harding C , Steven J. P. McInnes C , Sameer Al-Bataineh C and Nicolas H. Voelcker C D
+ Author Affiliations
- Author Affiliations

A Faculty of Chemistry, Sensor and Biosensor Research Center (SBRC) and Nanoscience and Nanotechnology Research Center (NNRC), Razi University, Kermanshah, I.R. Iran.

B Department of Chemistry, Bandar Jask Branch,Islamic Azad University, Bandar Jask, Iran.

C ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Mawson Institute, University of South Australia, Adelaide, SA 5001, Australia.

D Corresponding authors. Emails: nico.voelcker@unisa.edu.au; kashanian_s@yahoo.com

Australian Journal of Chemistry 69(2) 204-211 https://doi.org/10.1071/CH15315
Submitted: 31 May 2015  Accepted: 10 July 2015   Published: 31 August 2015

Abstract

Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50 % and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.


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