Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
REVIEW

Perspectives on the Molecular and Biological Implications of Tropoelastin in Human Tissue Elasticity*

Anthony S. Weiss
+ Author Affiliations
- Author Affiliations

Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia. Email: tony.weiss@sydney.edu.au




Professor Anthony Weiss is the McCaughey Chair in Biochemistry and Professor of Biochemistry and Molecular Biotechnology at the University of Sydney. He is a Fellow of the Royal Australian Chemical Institute, the Royal Society of Chemistry, the Australian Academy of Technological Sciences and Engineering, the American Institute for Medical and Biological Engineering, the Royal Society of Arts, and the Australian Institute of Company Directors. He is also a Fellow of Biomaterials Science and Engineering. He was recently awarded the 2015 RACI Applied Research Medal.

Australian Journal of Chemistry 69(12) 1380-1382 https://doi.org/10.1071/CH16452
Submitted: 2 August 2016  Accepted: 26 August 2016   Published: 14 September 2016

Abstract

The elasticity of a range of vertebrate and particularly human tissues depends on the dynamic and persistent protein elastin. This elasticity is diverse, and comprises skin, blood vessels, and lung, and is essential for tissue viability. Elastin is predominantly made by assembling tropoelastin, which is an asymmetric 20-nm-long protein molecule. This overview considers tropoelastin’s molecular features and biological interactions in the context of its value in tissue repair.


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