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RESEARCH ARTICLE
Contents Vol 71(6)

An Efficient One-Pot, Four-Component Synthesis of Pyrazolo[3,4-b]pyridines Catalyzed by Tetrapropylammonium Bromide (TPAB) in Water

Mahnaz Ezzati A , Jabbar Khalafy A C , Ahmad Poursattar Marjani A and Rolf H. Prager B
+ Author Affiliations
- Author Affiliations

A Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia 5756151818, Iran.

B Department of Chemistry, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.

C Corresponding author. Email: j.khalafi@urmia.ac.ir

Australian Journal of Chemistry 71(6) 435-441 https://doi.org/10.1071/CH17642
Submitted: 15 December 2017  Accepted: 15 April 2018   Published: 8 May 2018

Abstract

A novel and one-pot pseudo-four-component reaction between a series of arylglyoxals, malononitrile, 3-methyl-1-phenyl-1H-pyrazol-5-amine, and acetone in the presence of tetrapropylammonium bromide (TPAB) has been developed to synthesize a series of new substituted pyrazolo[3,4-b]pyridines, using water as an environmentally friendly solvent, in high to excellent yields.


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