A synthesis of two-protected nonpeptide amides with the amino acid sequence of oxytocin

Abstract

Two protected nonapeptide amides with the amino acid sequence of oxytocin have been synthesized by a route involving the use of benzyloxycarbonyl peptide p-nitrophenyl esters as coupling components. One of the products is a compound which has been described previously, and converted into oxytocin, by various authors. The present approach is discussed in relation to the earlier syntheses.