Alkaloids of the genus Cinnamomum. II. The alkaloids of the bark of Cinnamomum sp. T.G.H. 13077

Abstract

The major alkaloids of the bark of Cinnamomum sp. T.G.H. 13077 have been identified as the benzylisoquinolinea (+)-1-(4'-hydroxybenzyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (norcinnamolaurine) (l), (-)-cinnamolaurine (2), (+)-reticuline (3), and the aporphine (+)-corydine (4). The structure of norcinnamolaurine, a new alkaloid, was elucidated by N.M.R. and mass spectroscopy and was confirmed by conversion into cinnamolaurine and by synthesis of its racemate. 0.r.d. spectra indicate that both (-)-cinnamolaurine and (+)-norcinnamolaurine belong to the D-series of benzylisoquinoline alkaloids.