Chemistry of the Podocarpaceae. L. Conversion of 12-Hydroxypodocarpa-8,11,13-trien-19-oic acid (podocarpic acid) into 19-Hydroxypodocarp-8(14)-en-13-one

Abstract

Detosylations of derivatives of methyl 12-toluene-p- sulphonyloxypodocarpa-8,11,13-trien-19-oate have been investigated using a modified W-7 Raney nickel catalyst. The final steps in a conversion of podocarpic acid (1) into (+)-19-hydroxypodocarp-8(14)-en- 13-one (21), a useful intermediate for synthesis, have been effected.