Studies in 4-Aminothiazolines. VII. Use of bromomalononitrile in the synthesis of 4-Aminothiazoline-5-carbonitriles and their subsequent hydrolysis byorthophosphoric acid

Abstract

Bromomalononitrile on condensation with N-substituted thioureas furnished 4-amino-3-aryl(or allyl)-2-imino-4-thiazoline-5-carbonitriles (4). On acetylation in Ac₂O/AcOH, (4) gave first mono acetyl derivatives (5) and then diacetyl derivatives (6). Thiazolines (4) and acetyl derivatives (5) underwent hydrolysis with orthophosphoric acid to the corresponding amides (8) and (7) respectively.