New routes to 7-Alkyl-10-methylnaphtho[1,2-g]pteridine-9,11(7H,10H)-diones and 12-Alkyl-9-methylnaphtho[2,1-g]pteridine-8,10(9H,12H)-diones from naphthols

Abstract

2-(1-Nitronaphthalen-2-ylamino)ethanol, prepared from 2-methoxy-1- nitronaphthalene and 2-aminoethanol,can be reduced to 2-(1- aminonaphthalen-2-ylamino)ethanol which condenses with 1-methylalloxan to give 7-(2-hydroxyethyl)-10-methylnaphtho[1,2-g]pteridine- 9,11(7H,10H)-dione.    12-(2-Hydroxyethyl)-9-methylnaphtho[2,1-g]pteridine-8,10(9H,12H)- dione can be prepared by a similar reaction sequence from 1-methoxy-2- nitronaphthalene.