The preparation and central pharmacological action of stereoisomeric bicyclic imides

Abstract

The stereochemistry of the bicyclic imide, 4a-methyldecahydroisoquinoline-1,3-dione (1), has been defined, as has that of intermediates in its synthesis. Epimers of (1) exhibit dual stimulant-depressant central nervous system action in the mouse similar to that shown by 3-methyl-3-propylglutarimide.