New Macrocyclic Ligands. IX. N-Benzylated Macrocycles Incorporating O2N2-, O3N2- and O2N3-Donor Sets.

Abstract

The syntheses of N-benzylated macrocyclic ligands incorporating O₂N₂-, O₃N₂- and O₂N₃-donor sets, and ring sizes from 15- to 18-membered, is described. The new derivatives were obtained by benzylation of the previously reported parent macrocycles with benzyl bromide in acetonitrile containing suspended sodium carbonate or bicarbonate. The X-ray structure determination of a tribenzylated product containing a 17-membered, O₂N₃-donor macrocyclic ring is described.