Synthesis of Casein-Related Peptides and Phosphopeptides. XV. The Efficient Synthesis of Multiple-Ser(P)-Containing Peptides

Abstract

The synthesis of Ac-Ser(P)- NHMe and multiple-Ser(P)-containing peptides Ac-Ser(P)-Ser(P)-NHMe and Ac-Ser(P)-Ser(P)-Ser(P)- NHMe is described. The use of Boc -Ser(PO₃Ph₂)-OH in the Boc mode of peptide synthesis for the preparation of the protected Ser(PO₃Ph₂)-containing peptides was followed by platinum-mediated hydrogenolytic deprotection.