New and More Potent Antifungal Disulfides
Felix Jakob Baerlocher, Mark Otto Baerlocher, Richard Francis Langler, Stephanie Lee MacQuarrie and Maurice Emile Marchand
Australian Journal of Chemistry
53(1) 1 - 5
Published: 2000
Abstract
From a design principle described in an earlier paper, a new series of substituted aryl methyl disulfides have been prepared and tested against Aspergillus niger and Aspergillus flavus. Methyl p-nitrophenyl disulfide is more potent (by an order of magnitude) than the fungitoxic natural product (CH3SCH2S)2. With the present rationale in hand, one can anticipate which Polycarpamine is an effective antifungal agent.Keywords: Antifungal; disulfides; structure– activity relationship; synthesis.
https://doi.org/10.1071/CH99139
© CSIRO 2000
