The Synthesis of Optically Pure β-Cyclopiazonic Acid, an Indolic Fungal Metabolite

Abstract

The chiral synthesis of the fungal metabolite β- cyclopiazonic acid is described. The key step involves the use of the tricarbonylchromium complex of an N-protected L- tryptophan methyl ester as a substrate for the addition/oxidation method of substitution of its indole ring system.