Reproduction, Fertility and Development Reproduction, Fertility and Development Society
Vertebrate reproductive science and technology
RESEARCH ARTICLE

Effects of fetal genotype and sex on developmental response to maternal malnutrition

Laura Cogollos A , Consolacion Garcia-Contreras B , Marta Vazquez-Gomez C , Susana Astiz A , Raul Sanchez-Sanchez A , Ernesto Gomez-Fidalgo A , Cristina Ovilo B , Beatriz Isabel C and Antonio Gonzalez-Bulnes A D E
+ Author Affiliations
- Author Affiliations

A Department of Animal Reproduction, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.

B Department of Animal Genetics, INIA, Ctra. De A Coruña Km. 7, 28040 Madrid, Spain.

C Faculty of Veterinary Sciences, UCM, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.

D Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.

E Corresponding author. Email: bulnes@inia.es

Reproduction, Fertility and Development 29(6) 1155-1168 https://doi.org/10.1071/RD15385
Submitted: 27 September 2015  Accepted: 15 March 2016   Published: 17 May 2016

Abstract

The present study aimed to determine whether developmental patterns, adiposity level and fatty-acid composition of fetuses exposed to maternal malnutrition are driven by their sex or their genotype, or both, as these may modulate the adaptive response to the intrauterine environment independently of the maternal genotype. We used a single maternal genotype (purebred Iberian (IB) sows), which was inseminated with heterospermic semen (obtained by mixing semen from Iberian and Large White (LW) boars), to obtain four different subsets of fetuses (male and female, purebred (IB × IB) and crossbred (IB × LW)) in Iberian purebred sows. Analysis of fetal phenotypes indicated a better adaptive response of the female offspring, which was modulated by their genotype. When faced with prenatal undernutrition, females prioritised the growth of vital organs (brain, liver, lungs, kidneys and intestine) at the expense of bone and muscle. Moreover, the analysis of fat composition showed a higher availability of essential fatty acids in the female sex than in their male counterparts and also in the Iberian genotype than in crossbred fetuses. These results are of high translational value for understanding ethnic differences in prenatal programming of postnatal health and disease status, and show evidence that prenatal development and metabolic traits are primarily determined by fetal sex and strongly modulated by fetal genotype.

Additional keywords: developmental programming, ethnicity, fatty acids.


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