Reproduction, Fertility and Development Reproduction, Fertility and Development Society
Vertebrate reproductive science and technology

Chromosomal position effects and the modulation of transgene expression

AJ Clark, P Bissinger, DW Bullock, S Damak, R Wallace, CB Whitelaw and F Yull

Reproduction, Fertility and Development 6(5) 589 - 598
Published: 1994


Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.

© CSIRO 1994

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