Via hydrothermal synthesis, we constructed four nucleobase-based metal-organic compounds. These polymers show novel 2D and 3D structures, such as three-interpenetrating dmp net, supramolecular zeolite-type sra net, and exceptional 2D 44 net composed of three kinds of quadrangle, observed in polymer 1, 2, and 3, respectively. Moreover, thermogravimetric studies of polymers 1, 2, and 4, and the magnetic properties of 3 are also explored.
The reactions of the HBr molecule with CH2CH2Cl (R1), CH2CHCl2 (R2), CH2CH2Br (R3), and CH2CHBr2 (R4) are investigated theoretically by a dual-level direct dynamics method. Using the canonical variational transition state theory (CVT) or CVT with the small-curvature tunnelling (SCT) correction, the rate constants are calculated over a wide temperature range of 200–2000 K at the G2M(RCC5)//MPW1K/6–311+G(d,p) level. The effect of chlorine or bromine substitution on the ethyl radical reactivity is discussed.
The synthesis of some novel N-tosyl tetra and diaza cyclophanes incorporating m-terphenyl as spacer units is described. All the N-tosyl aza cyclophanes exhibit excellent anti-arthritic and anti-inflammatory activity.
The alkaline hydrolysis of hydrophobic triphenylmethane dye (ethyl violet) is inhibited in sodium dodecyl sulfate mixed micellar systems with various nonionic surfactants, due to repulsion of OH¯ ions by the negatively charged micellar aggregates. Positive cooperativity model of enzyme catalysis is successfully applied for quantitative analysis of micellar data.
Derivatives 4a–d of the novel diindeno[1,2-g:1′,2′-s]rubicene ring system have been prepared in three steps from 1,5-dichloroanthraquinone. The photophysical properties of this novel ring system and a correlation of the organic field-effect transistors’ performance with X-ray crystallographic analyses are reported.
The Editor-in-Chief wishes the readers a very happy, enjoyable, and successful new year and announces the imminent appointment of four new Associate Editors.
The 2nd International Nanomedicine Conference in Coogee was held in July 2011, and brought together the top minds in a discipline that crosses borders incorporating medicine, chemistry, and engineering. This Research Front, dedicated to Nanomedicine, comprises a selection of papers epitomizing the current sentiments in this emerging field.
Specific killing of cancer cells using enhanced permeability retention effect (EPR) efficacy , with reduced side effects was studied during the recent developments in nano-technology. This review discussed the active targeting towards cancer cell with specific ligands incorporated in biodegradable polymeric nanocarriers to improve the bio-activity of the encapsulated cargo.
The self-assembly of silver nanoparticles using triglycine as an organic template, and their subsequent self-assembly into one-dimensional nanostructures under ambient temperature in the presence of copper cations is reported.
The time evolution of gold nanoparticles produced by laser ablation synthesis in solution (LASiS) as a function of sodium dodecyl sulfate concentration in aqueous solution is explained in terms of a simple kinetic model. Transmission electron microscopy studies show that the nanoparticle size distributions are not influenced by surfactant micelles.
Calendula oil/chitosan microcapsules prepared by simple coacervation are reported. The optimal parameter combinations are determined. The in vitro and in vivo toxicity evaluation demonstrate that the microcapsules exhibit no significant toxicological effects on human keratinocytes and mice. The microcapsules are suggested as safe drug carriers both topically and orally.
A new kind of alkaline earth-based alkalide M2+(H5Azacryptand[2.2.2]–)M′–·2MeNH2 (M = Be, Mg, Ca; M′ = Li, Na, K) exhibits unusually large non-linear optical (NLO) properties.
Solid-phase methylamine was VUV photoprocessed at low temperature (20 K). The use of CO as an H radical scavenger gave new insights about the photomechanisms of methylamine photodestruction as well as new possible ways for the formation of amides in the interstellar medium.
This paper reviews work carried out in the Centre for Biospectroscopy, Monash University, at the Infrared Microspectroscopy Beamline on the Australian Synchrotron since the first synchrotron light. It discusses the attributes and advantages of the beamline for chemical spectroscopy and imaging of cellular and tissue samples and briefly summarizes new techniques that will come online in the near future.
Mesoporous chromia films deposited onto 300–400-nm gap ITO junction electrodes reveal both mobile and trapped surface charges during oxidation.
The ability of synchrotron X-ray powder diffraction measurements to establish structures of perovskite oxides is discussed using CdTiO3 and the series Ba2-xSrxInTaO6.
Reductively degradable hyperbranched polymers with multiple peripheral alkyl bromide groups were synthesized by the radical copolymerization of di- or oligo(ethylene oxide) methyl ether methacrylate with the disulfide-containing crosslinker bis(2-methacryloyloxyethyl)disulfide. The polymers were used as multifunctional atom-transfer radical polymerization macroinitiators, which were chain-extended to yield star copolymers with hyperbranched disulfide-containing cores. Both the macroinitiators and the star copolymers derived from them degraded in the presence of a reducing agent.
This review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist.
The one-step conversion of benzopyranones to the heptacyclic spiroacetal core of cynandione B using methylmagnesium bromide has been achieved. The process involves a tandem Grignard addition/aldol/spiroacetal forming reaction sequence. X-ray crystal structure analysis has established the relative configuration in these novel heterocyclic products.
Fluoride ion is adsorbed at the hydroxide-charged air/water interface slightly more strongly than the other halide anions.
The formation of phosphinidenoid complex salts having weakly coordinating cations (WCCs) is reported via treatment of P-functional phosphane complexes with N,N’-di-tert-butyl imidazol-2-ylidene or a P4-t-Bu phosphazene base. The thermal stability of phosphinidenoid complex salts is dependent upon the P–X substituents and the nature of the WCC.
A series of well-defined semitelechelic and mid-functionalized poly(poly(ethylene glycol) methyl ether methacrylate)s (poly(PEGMA)s) were synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization using thiazolidine-2-thione-functionalized chain transfer agents (CTAs). The thiazolidine-2-thione functionality located at the end of or at the middle of the polymer chains can react with amine residues on protein surfaces, forming protein-polymer conjugates via amide linkages. The protein conjugations from the mid-functionalized polymer remained much more protein bioactive compared to their semitelechelic counterpart with similar molecular weights, indicating that the steric hindrance of the mid-functionalized poly(PEGMA)s leads to the better selective conjugation to the protein. This synthetic methodology is suitable for universal proteins, seeking a balance between the protein bioactivity and the protein protection by the covalent linkage with polymers, and exhibits promising potential for pharmaceutical protein conjugation.
[Ag2(mptrz)(μ3-X)]n (X = I (1) and Br (2)) and [Pb4(μ4-O)(mptrz)4(μ2-X)] (X = I (3) and Cl (4)) have been synthesized. Compounds 1 and 2 have 2D layered structures with unique inorganic [Ag2X2]n chains. Compounds 3 and 4 are discrete tetranuclear lead(ii) cluster compounds featuring oxygen-centred Pb4(µ4-O) tetrahedra. All compounds display fluorescent emission.
Polyelectrolytes composed of suitably hydrophobic ions exhibited temperature-sensitive LCST-type phase transitions after mixing with water.
The thioglycolate anion reacts with BrMn(CO)5 to form a dimeric complex of formula [Mn2(thioglycolate)2(CO)6]2–.