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RESEARCH ARTICLE

Diagnosis of latent tuberculosis infection among HIV-infected clients in Far North Queensland: use of an interferon-gamma release assay

Katrina Lyne A C , Sandra Downing B and Darren Russell B
+ Author Affiliations
- Author Affiliations

A Cairns Base Hospital, Cairns, QLD 4870, Australia.

B Cairns Sexual Health Service, Cairns, Qld 4870, Australia.

C Corresponding author. Email: katrina.lyne@gmail.com

Sexual Health 10(4) 389-390 https://doi.org/10.1071/SH12167
Submitted: 8 October 2012  Accepted: 21 February 2013   Published: 17 May 2013

Abstract

Latent Mycobacterium tuberculosis infection is a significant risk for those infected with HIV. We examined the use of an interferon-gamma release assay for the diagnosis of latent tuberculosis among HIV-infected clients attending two sexual health services in Far North Queensland. Of 240 clients tested, 19 returned a positive result (7.9%, 95% confidence interval (CI): 4.5–11.3%) and three were indeterminate (1.3%, 95% CI: –0.2%–2.7%). Low CD4 count was found to be significantly associated with an indeterminate test result (P = 0.004). However, we found no significant association between test results and client demographics, self-reported prior tuberculosis infection, Bacille Calmette-Guérin vaccine status or selected tuberculosis risk factors (P-values = 0.2–0.9).

Additional keywords: diagnosis, interferon-gamma release tests, Mycobacterium tuberculosis.


References

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