Coalescent Theory

cover of Coalescent Theory

Presents the mathematics of gene genealogies for biologists at the graduate and post-graduate level and for mathematicians interested in biology.

Coalescent theory provides the foundation for molecular population genetics and genomics. It is the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data.

Coalescent Theory: An Introduction presents the mathematics of gene genealogies for biologists at the graduate and post-graduate level and for mathematicians interested in biology.

Contents

Gene Genealogies and Genetic Data
Probability Theory for the Coalescent
The Coalescent
Neutral Mutations and Genetic Polymorphisms
Population Structure
Splitting Lineages: Recombination and Weak Selection
Separation of Time Scales and Robustness Results
Simulations and Simulation-based Methods
Solutions to Odd-Numbered Exercises
Bibliography
Index