Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH FRONT

Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

Candy K. Y. Chun A and Richard J. Payne A B

A School of Chemistry, The University of Sydney, NSW 2006, Australia.

B Corresponding author. Email: payne@chem.usyd.edu.au

Australian Journal of Chemistry 62(10) 1339-1343 http://dx.doi.org/10.1071/CH09282
Submitted: 12 May 2009  Accepted: 19 June 2009   Published: 13 October 2009

Abstract

Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.


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