Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH FRONT

Recent Advances in Mapping the Sub-cellular Distribution of Metal-Based Anticancer Drugs

Louise E. Wedlock A B and Susan J. Berners-Price B C

A School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth, WA, 6009, Australia.

B Institute for Glycomics, Griffith University, Gold Coast Campus, Qld 4222, Australia.

C Corresponding author. Email: s.berners-price@griffith.edu.au




Louise Wedlock received her BSc (Hons) in 2005 from the University of Western Australia, when she received the A. R. H. Cole Honours Prize in Inorganic Chemistry for her work on mapping the sub-cellular distribution of dinuclear fluorescent gold(I) complexes. In 2011 she was awarded her PhD from the University of Western Australia, focusing on the synthesis and spectroscopic properties of gold(I) complexes, and the development of novel imaging techniques for studying the distribution of metal complexes inside tumour cells. She is currently a Research Fellow in the Institute for Glycomics at Griffith University. Her research interests are in medicinal inorganic chemistry and imaging.



Sue Berners-Price received her PhD in Chemistry from Birkbeck College, University of London in 1985 and then moved to Australia as the Royal Society Florey Fellow. In 1990 she was appointed to a Lectureship at Griffith University, Brisbane Australia and from 1992 to 1995 she was holder of an NH&MRC R. Douglas Wright Award. In 2001 she moved to Perth to take up the appointment as Professor of Biological Chemistry at the University of Western Australia. Since 2009 she has been Pro Vice Chancellor (Science, Environment, Engineering and Technology) at Griffith University, where she is also a Professor in the Institute for Glycomics. Her research interests are in the area of medicinal inorganic chemistry and NMR spectroscopy and she has a long-standing interest in the development of gold-based anticancer agents.

Australian Journal of Chemistry 64(6) 692-704 http://dx.doi.org/10.1071/CH11132
Submitted: 5 April 2011  Accepted: 8 May 2011   Published: 27 June 2011

Abstract

There are increasing reports of novel metal-based chemotherapeutics that have either improved cancer cell selectivity, or alternative mechanisms of action, to existing anticancer drugs, and techniques are required for determining their sub-cellular molecular targets. Imaging methods offer many distinct advantages over destructive fractionation techniques, including the preservation of useful morphological information; however, mapping the intracellular distribution of metal ions inside tumour cells still remains challenging. Recent advances in three modes of imaging are discussed in this review, with a particular focus on the application to metal-based cancer chemotherapy – fluorescence microscopy, electron microscopy (including energy-filtered transmission electron microscopy (EFTEM)), and a new technique, Nano-scale secondary ion mass spectrometry (NanoSIMS).

Graphical Abstract Image


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