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RESEARCH FRONT
Contents Vol 66(2)

Flow Microwave Technology and Microreactors in Synthesis

Ian R. Baxendale A E , Christian Hornung B , Steven V. Ley C , Juan de Mata Muñoz Molina C and Anders Wikström D
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK.

B CSIRO Materials Science & Engineering, Clayton South, Vic. 3169, Australia.

C Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

D Biotage Sweden AB, Kungsgatan 76, SE-753 18 Uppsala, Sweden.

E Corresponding author. Email: i.r.baxendale@durham.ac.uk

Australian Journal of Chemistry 66(2) 131-144 https://doi.org/10.1071/CH12365
Submitted: 2 August 2012  Accepted: 5 September 2012   Published: 8 October 2012

Abstract

A bespoke microwave reactor with a glass containment cell has been developed for performing continuous flow reactions under microwave heating. The prototype unit has been evaluated using a series of standard organic chemical transformations enabling scale-up of these chemical processes. As part of the development, a carbon-doped PTFE reactor insert was utilized to allow the heating of poorly absorbing reaction media, increasing the range of solvents and scope of reactions that can be performed in the device.


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