Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
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Continuous Flow Synthesis of Difluoroamine Systems by Direct Fluorination

Christopher B. McPake A , Christopher B. Murray B C and Graham Sandford A C

A Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.

B AWE, Aldermaston, Reading, Berkshire, RG7 4PR, UK.

C Corresponding authors. Email: christopher.murray@awe.co.uk; graham.sandford@durham.ac.uk

Australian Journal of Chemistry 66(2) 145-150 http://dx.doi.org/10.1071/CH12381
Submitted: 15 August 2012  Accepted: 27 September 2012   Published: 17 January 2013

Abstract

Continuous flow methodology for the synthesis of perfluoroaryl difluoroamine derivatives by reaction of fluorine gas with an appropriate perfluoroaniline substrate is described, further demonstrating the efficient use of flow regimes for reactions involving highly reactive and toxic reagents.

Graphical Abstract Image


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