Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Eco-Friendly Synthesis of 2-Substituted Benzimidazoles Using Air as the Oxidant

Guo-Feng Chen A D , Hai-Dong Shen A , Hui-Ming Jia A , Li-Yan Zhang A , Hong-Yan Kang A , Qing-Qing Qi A , Bao-Hua Chen B , Jia-Li Cao C and Ji-Tai Li A

A College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002, China.

B College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.

C Aviation Industry Corporation of China, Beijing Institute of Aeronautical Materials, Beijing 100095, China.

D Corresponding author. Email: chenguofeng@hbu.cn

Australian Journal of Chemistry 66(2) 262-266 http://dx.doi.org/10.1071/CH12458
Submitted: 7 October 2012  Accepted: 5 December 2012   Published: 7 January 2013

Abstract

A simple, environmentally friendly procedure for the synthesis of 2-substituted benzimidazoles by the one-pot condensation of o-phenylenediamines with aromatic aldehydes using continuous bubbling of air in absolute ethanol at room temperature is described. The simplicity of the system, mild conditions, involvement of a non-toxic and practically inexhaustible oxidant, easy and quick isolation of the products, and moderate to good yields are the main advantages of this procedure.


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