Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Formation of Advanced Glycation End Products (AGEs) are Influenced by Lipids in Milk Powders

Ling Liu A B , Rikke V. Hedegaard B and Leif H. Skibsted B C
+ Author Affiliations
- Author Affiliations

A The College of Food Science, Shenyang Agricultural University, Shenyang, Dongling Street No. 120, China.

B Food Chemistry, Department of Food Science, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark.

C Corresponding author. Email: ls@life.ku.dk

Australian Journal of Chemistry 66(9) 1074-1079 https://doi.org/10.1071/CH13081
Submitted: 19 February 2013  Accepted: 17 June 2013   Published: 11 July 2013

Abstract

Advanced glycation end products (AGEs) were determined by a polyclonal ELISA method in three milk powders of varying lipid content, during storage in sealed containers at 65°C for up to 20 days. AGEs content correlated with increased water activity (aw), decreased glass transition temperature (Tg), increased lactose crystallisation, and browning in the three milk powders. Formation of stable radicals as detected by electron spin resonance spectroscopy correlated with crystallisation of lactose and brown discoloration in the three powders indicating origin from Maillard reactions rather than lipid oxidation. AGEs content was greatest in whole milk powder with highest lipid content, while in butter milk powder formation of secondary lipid oxidation products increased faster as determined by thiobarbituric acid reactive substances.


References

[1]  J. Uribarri, S. Woodruff, S. Goodman, W. J. Cai, X. Chen, R. Pyzik, A. Yong, G. E. Striker, H. Vlassara, J. Am. Diet. Assoc. 2010, 110, 911.
         | CrossRef | 20497781PubMed | open url image1

[2]  F. J. Hidalgo, R. Zamora, Aging Dis. 2005, 1043, 319.
         | 1:CAS:528:DC%2BD2MXpvVKqtro%3D&md5=c0af66ccfad3409683edfaca7f2b3122CAS | open url image1

[3]  M. N. Lund, K. Olsen, J. Sorensen, L. H. Skibsted, J. Agric. Food Chem. 2005, 53, 2095.
         | CrossRef | 1:CAS:528:DC%2BD2MXhsVamtb8%3D&md5=b8b43af57b6b01b00ea803826f0c0befCAS | 15769141PubMed | open url image1

[4]  K. Andersson, H. Lingnert, LWT - Food Sci. Technol. 1998, 31, 169.
         | CrossRef | 1:CAS:528:DyaK1cXjs1Wqtrg%3D&md5=0e98930f7212bbc95dbbfe65a5a20816CAS | open url image1

[5]  F. J. Morales, M. A. J. S. van Boekel, Int. Dairy J. 1997, 7, 675.
         | CrossRef | 1:CAS:528:DyaK1cXjslSjsb4%3D&md5=d5173d5338a109fc3f07a92c3067feeaCAS | open url image1

[6]  H. Stapelfeldt, B. R. Nielsen, L. H. Skibsted, Int. Dairy J. 1997, 7, 331.
         | CrossRef | 1:CAS:528:DyaK1cXnvVOqsw%3D%3D&md5=bffd4a0e5e5ea19d8f419e42c61bdeb6CAS | open url image1

[7]  M. K. Thomsen, L. Lauridsen, L. H. Skibsted, J. Risbo, J. Agric. Food Chem. 2005, 53, 1805.
         | CrossRef | 1:CAS:528:DC%2BD2MXhtFegtr4%3D&md5=2e9a631e0fe26d09ecc1934e811696caCAS | 15740077PubMed | open url image1

[8]  L. S. Malec, A. S. P. Gonzales, G. B. Naranjo, M. S. Vigo, Food Res. Int. 2002, 35, 849.
         | CrossRef | 1:CAS:528:DC%2BD38XntVWmtrY%3D&md5=b26fc0204bd48cdd8b4e5ca3fbe0fefeCAS | open url image1

[9]  G. L. J. Hull, J. V. Woodside, J. M. Ames, G. J. Cuskelly, Food Chem. 2012, 131, 170.
         | CrossRef | 1:CAS:528:DC%2BC3MXht1OrtL7P&md5=a864a6b47ff6d1f8d791d7b6f993235dCAS | open url image1

[10]  D. Kilburn, S. Townrow, V. Meunier, R. Richardson, A. Alam, J. Ubbink, Nat. Mater. 2006, 5, 632.
         | CrossRef | 1:CAS:528:DC%2BD28XnsFeitbo%3D&md5=0b2f68b068605e2c835ffa41974c6b9cCAS | 16845422PubMed | open url image1

[11]  Y. H. Roos, Lait 2002, 82, 475.
         | CrossRef | 1:CAS:528:DC%2BD38Xns1elsr4%3D&md5=f78c5a9b9783a34269a3d5cf48926f52CAS | open url image1

[12]  L. Slade, H. Levine, Crit. Rev. Food Sci. Nutr. 1991, 30, 115.
         | CrossRef | 1:CAS:528:DyaK3MXlsFOhsrY%3D&md5=7e39d3b730a501ac58c47b4599ceb5a4CAS | 1854434PubMed | open url image1

[13]  K. Jouppila, J. Kansikas, Y. H. Roos, J. Dairy Sci. 1997, 80, 3152.
         | CrossRef | 1:CAS:528:DyaK1cXht1ynsA%3D%3D&md5=d9eca8c2782e16cb9e56330f75b313c7CAS | open url image1

[14]  N. Ozkan, N. Walisinghe, X. D. Chen, J. Food Eng. 2002, 55, 293.
         | CrossRef | open url image1

[15]  M. K. Thomsen, L. Jespersen, K. Sjostrom, J. Risbo, L. H. Skibsted, J. Agric. Food Chem. 2005, 53, 9182.
         | CrossRef | 1:CAS:528:DC%2BD2MXhtFegs7%2FM&md5=d78052c44d9671bb9ec27abd6f2574e3CAS | 16277420PubMed | open url image1

[16]  K. Kikugawa, Adv. Free Radic. Biol. Med. 1986, 2, 389.
         | CrossRef | 1:CAS:528:DyaL2sXpvVWktQ%3D%3D&md5=11483ebc0008ac465672cf496e96817eCAS | open url image1

[17]  S. B. Matiacevich, P. R. Santagapita, M. P. Buera, Crit. Rev. Food Sci. Nutr. 2005, 45, 483.
         | CrossRef | 1:CAS:528:DC%2BD2MXhtV2gsrzM&md5=e85e644b65d22c18b35184e0353f841dCAS | 16183569PubMed | open url image1

[18]  M. A. J. S. Van Boekel, Food Chem. 1998, 62, 403.
         | CrossRef | 1:CAS:528:DyaK1cXlsV2nu7s%3D&md5=b7713d6efab25bc4ca2a79a353435987CAS | open url image1

[19]  J. H. Liang, Food Chem. 2000, 71, 459.
         | CrossRef | 1:CAS:528:DC%2BD3cXmvFOkurs%3D&md5=466fe6783acd288c947d85e907ad4b61CAS | open url image1

[20]  J. C. Astaire, R. Ward, J. B. German, R. Jimenez-Flores, J. Dairy Sci. 2003, 86, 2297.
         | CrossRef | 1:CAS:528:DC%2BD3sXltlSrt7c%3D&md5=e9ce8f864b7c38024821c75e504f20bcCAS | 12906046PubMed | open url image1

[21]  G. Litwinienko, J. Therm. Anal. Calorim. 2001, 65, 639.
         | CrossRef | 1:CAS:528:DC%2BD3MXnt1yjsL4%3D&md5=b2c98b4642a37a013f5f7ffd9e742d1dCAS | open url image1

[22]  C. Delgado-Andrade, J. A. Rufian-Henares, F. J. Morales, J. Agric. Food Chem. 2005, 53, 7832.
         | CrossRef | 1:CAS:528:DC%2BD2MXpsl2qs74%3D&md5=e9f9c8510efa0984817ee4a80e71c7bcCAS | 16190638PubMed | open url image1

[23]  K. H. Wagner, S. Derkits, M. Herr, W. Schuh, I. Elmadfa, Food Chem. 2002, 78, 375.
         | CrossRef | 1:CAS:528:DC%2BD38XlvFOksrw%3D&md5=e16ac158e77224a2b7d5a8bf1628a207CAS | open url image1

[24]  Y. Yilmaz, R. Toledo, Food Chem. 2005, 93, 273.
         | CrossRef | 1:CAS:528:DC%2BD2MXkt1als7g%3D&md5=ff5dcabfd7e0b1f2c5a4c25c16020c31CAS | open url image1

[25]  G. C. Yen, P. P. Hsieh, J. Sci. Food Agric. 1995, 67, 415.
         | CrossRef | 1:CAS:528:DyaK2MXksV2lur0%3D&md5=29202c9bd71387552f40f2888a67c3b9CAS | open url image1

[26]  M. K. Thomsen, J. C. Knudsen, J. Risbo, L. H. Skibsted, Milchwissenschaft 2003, 58, 406. open url image1

[27]  G. P. Rizzi, Food Rev. Int. 2003, 19, 375.
         | CrossRef | 1:CAS:528:DC%2BD3sXotlSjurw%3D&md5=6f519e300ae4f5db1acda56862611e62CAS | open url image1

[28]  H. Stapelfeldt, B. R. Nielsen, L. H. Skibsted, Milchwissenschaft 1997, 52, 682.
         | 1:CAS:528:DyaK1cXhsVSqtw%3D%3D&md5=f16b26a9debc13e17ffd15c2b53f8310CAS | open url image1

[29]  M. K. Thomsen, D. Kristensen, L. H. Skibsted, J. Am. Oil Chem. Soc. 2000, 77, 725.
         | CrossRef | 1:CAS:528:DC%2BD3cXltlGksLs%3D&md5=5b3ae27f1ca9cb2b7b26755c1084e5f2CAS | open url image1

[30]  T. Hofmann, W. Bors, K. Stettmaier, J. Agric. Food Chem. 1999, 47, 391.
         | CrossRef | 1:CAS:528:DyaK1MXkvFymtQ%3D%3D&md5=18040418826b910984bb37bae9268a6aCAS | 10563905PubMed | open url image1

[31]  K. Ikeda, T. Higashi, H. Sano, Y. Jinnouchi, M. Yoshida, T. Araki, S. Ueda, S. Horiuchi, Biochemistry 1996, 35, 8075.
         | CrossRef | 1:CAS:528:DyaK28XjtF2jt7w%3D&md5=dc2afc488662db84adaaac81287c5461CAS | 8672512PubMed | open url image1

[32]  P. Papanastasiou, L. Grass, H. Rodela, A. Patrikarea, D. Oreopoulos, E. P. Diamandis, Kidney Int. 1994, 46, 216.
         | CrossRef | 1:STN:280:DyaK2M%2FhvFCguw%3D%3D&md5=d3031d1c1239b0703fee472b16307d1eCAS | 7933840PubMed | open url image1

[33]  S. Jongberg, M. Rasmussen, L. H. Skibsted, K. Olsen, Aust. J. Chem. 2012, 65, 1620.
         | CrossRef | 1:CAS:528:DC%2BC38XhvVWgs7%2FE&md5=3dda48ad51b8898e517b774f099c9c5eCAS | open url image1

[34]  F. J. Hidalgo, F. Nogales, R. Zamora, J. Food Sci. 2005, 70, c387.
         | CrossRef | 1:CAS:528:DC%2BD2MXosVenu7g%3D&md5=90a9fb142760b89215f5fac3bbaabcaaCAS | open url image1

[35]  H. Stapelfeldt, G. Mortensen, L. H. Skibsted, Milchwissenschaft 1997, 52, 266.
         | 1:CAS:528:DyaK2sXjs12nurY%3D&md5=ed5509bc12352ee5724d01cfbf0f3c92CAS | open url image1

[36]  S. Reddy, J. Bichler, K. J. Wellsknecht, S. R. Thorpe, J. W. Baynes, Biochemistry 1995, 34, 10872.
         | CrossRef | 1:CAS:528:DyaK2MXnsVKrtbY%3D&md5=c94ace491a084e0745971aaf853dd51fCAS | 7662668PubMed | open url image1

[37]  B. R. Nielsen, H. Stapelfeldt, L. H. Skibsted, Int. Dairy J. 1997, 7, 589.
         | CrossRef | 1:CAS:528:DyaK1cXit1yrt7Y%3D&md5=d52adc93ad64bd5b6b9f086b0dc453efCAS | open url image1

[38]  F. J. Morales, M. A. J. S. van Boekel, Int. Dairy J. 1998, 8, 907.
         | CrossRef | 1:CAS:528:DyaK1MXjtVGms70%3D&md5=0ee6f329de36cb55a7d72395d4d778c0CAS | open url image1

[39]  W. M. Baisier, T. P. Labuza, J. Agric. Food Chem. 1992, 40, 707.
         | CrossRef | 1:CAS:528:DyaK38XitlCjurs%3D&md5=f2c4a2a414cee1c571e7edba7da1f7c8CAS | open url image1

[40]  H. Stapelfeldt, L. H. Skibsted, Lipids 1996, 31, 1125.
         | CrossRef | 1:CAS:528:DyaK28XntVOgtL4%3D&md5=ccf548ac9d0013413bf405aa8befe765CAS | 8934444PubMed | open url image1



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