Multicomponent Synthesis of Novel 2-Aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles using CuI as Catalyst and their Antimicrobial Evaluation

Jayant Sindhu; Harjinder Singh; Jitender Mohan Khurana; Chetan Sharma; Kamal Rai Aneja

doi:10.1071/CH13082

RESEARCH ARTICLE

Previous Contents Vol 66(6)

Multicomponent Synthesis of Novel 2-Aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles using Cu^I as Catalyst and their Antimicrobial Evaluation

Jayant Sindhu ^A , Harjinder Singh ^A , Jitender Mohan Khurana ^A ^C , Chetan Sharma ^B and Kamal Rai Aneja ^B

+ Author Affiliations

- Author Affiliations

^A Department of Chemistry, Delhi University, Delhi 110007, India.

^B Department of Microbiology, Kurukshetra University Kurukshetra, Kurukshetra 136119, Haryana, India.

^C Corresponding author. Email: jmkhurana@chemistry.du.ac.in

Australian Journal of Chemistry 66(6) 710-717 https://doi.org/10.1071/CH13082
Submitted: 19 February 2013 Accepted: 2 April 2013 Published: 27 May 2013

Abstract

A series of novel 2-aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles have been synthesised by C–S bond formation and azide–alkyne cyclocondensation between [5-(aryl)-[1,3,4]oxadiazol-2-yl]methanethiol, propargyl bromide, and substituted aryl azides in one pot with an aim to explore their effect on the in vitro growth of microorganisms causing microbial infection. In vitro antibacterial activity was determined against four strains, namely Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and antifungal activity against two fungal strains, namely Aspergillus niger and Aspergillus flavus.

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Multicomponent Synthesis of Novel 2-Aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles using CuI as Catalyst and their Antimicrobial Evaluation

Abstract

References

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Multicomponent Synthesis of Novel 2-Aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles using Cu^I as Catalyst and their Antimicrobial Evaluation