Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
REVIEW

Biomedical Applications of Clay

Wojciech Chrzanowski A E , Sally Yunsun Kim A and Ensanya Ali Abou Neel B C D

A Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia.

B Division of Biomaterials, Conservative Dental Sciences Department, King Abdulaziz University, Jeddah 22254, Saudi Arabia.

C Biomaterials Department, Faculty of Dentistry, Tanta University, Tanta 31111, Egypt.

D Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray’s Inn Road, London, WC1X 8LD, UK.

E Corresponding author. Email: wchrzanowski@sydney.edu.au




A/Prof. Ensanya A. Abou Neel is currently an assistant professor at the Faculty of Dentistry, King Abdulaziz University, Saudi Arabia. Her scientific interests centre on novel bioactive glasses, biomimetic/synthetic polymers, and degradable/non-degradable composite materials for biomedical and tissue engineering applications.



Ms Sally Kim received her Bachelor of Pharmacy from the University of Sydney and is a registered pharmacist. She is pursuing her Master of Philosophy (Pharmacy) degree and her research is focused on the development of new classes of bio-inspired, multifunctional drug-carriers for pulmonary delivery of drugs using natural materials such as clay, silk, and keratin.



Dr Wojciech Chrzanowski is currently a lecturer at the University of Sydney. His research centres around biointerfaces and nanomedicine. His work involves developing drug delivery systems composed of natural materials such as lipids, clay, and silk. An important feature of these systems is their multifunctionality that allows controlled drug delivery (also externally activated) and supports biological processes such as tissue regeneration.

Australian Journal of Chemistry 66(11) 1315-1322 http://dx.doi.org/10.1071/CH13361
Submitted: 9 July 2013  Accepted: 19 August 2013   Published: 23 September 2013

Abstract

Traditional applications of clay mineral mainly revolved around cosmetics and industrial products, but their scope of application is continuously expanding into pharmaceutics including drug delivery and tissue engineering. The interest in clays amongst the scientific community has increased dramatically in recent years due to its composition and structure which can be easily modified to serve different purposes. Largely due to structural flexibility and its small particle size, clay nanostructure can be modified to tune rheological and mechanical properties, and can entrap moisture to suit a particular application. Additionally, interest in the synthesis of polymer-clay nanocomposites in tissue engineering is growing as it is cheap, easily available, and environmentally-friendly. The structure of clay allows the interclaysion of different biomolecules between the clay layers. These biomolecules can be released in a controlled manner which can be utilised in drug delivery and cosmetic applications.

Graphical Abstract Image


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