Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH FRONT

3D-Printable Biodegradable Polyester Tissue Scaffolds for Cell Adhesion

Justin M. Sirrine A , Allison M. Pekkanen B , Ashley M. Nelson A , Nicholas A. Chartrain C , Christopher B. Williams D and Timothy E. Long A B E
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, Macromolecules and Interfaces Institute, Virginia Tech, Blacksburg, VA 24061, USA.

B School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA.

C Department of Materials Science and Engineering, Virginia Tech, Blacksburg, VA 24061, USA.

D Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA 24061, USA.

E Corresponding author. Email: telong@vt.edu

Australian Journal of Chemistry 68(9) 1409-1414 https://doi.org/10.1071/CH15327
Submitted: 6 June 2015  Accepted: 7 July 2015   Published: 4 August 2015

Abstract

Additive manufacturing, or three-dimensional (3D) printing, has emerged as a viable technique for the production of vascularized tissue engineering scaffolds. In this report, a biocompatible and biodegradable poly(tri(ethylene glycol) adipate) dimethacrylate was synthesized and characterized for suitability in soft-tissue scaffolding applications. The polyester dimethacrylate exhibited highly efficient photocuring, hydrolyzability, and 3D printability in a custom microstereolithography system. The photocured polyester film demonstrated significantly improved cell attachment and viability as compared with controls. These results indicate promise of novel, printable polyesters for 3D patterned, vascularized soft-tissue engineering scaffolds.


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